Longitudinal Relationship Between Brain Atrophy Patterns, Cognitive Decline, and Cerebrospinal Fluid Biomarkers in Alzheimer's Disease Explored by Orthonormal Projective Non-Negative Matrix Factorization

• Published in: Journal of Alzheimer's disease Vol. 98; no. 3; p. 969
• Main Authors: Shui, Lan, Shibata, Dean, Chan, Kwun Chuen Gary, Zhang, Wenbo, Sung, Junhyoun, Haynor, David R
• Format: Journal Article
• Language: English
• Published: United States 01.01.2024
• Subjects: Alzheimer Disease - pathology; Amyloid beta-Peptides - cerebrospinal fluid; Atrophy - pathology; Biomarkers - cerebrospinal fluid; Brain - diagnostic imaging; Brain - pathology; Cognitive Dysfunction - pathology; Cross-Sectional Studies; Humans; Magnetic Resonance Imaging - methods; Neuropsychological Tests; tau Proteins - cerebrospinal fluid; magnetic resonance imaging; Alzheimer’s disease; biomarkers; brain atrophy; longitudinal studies

Longitudinal magnetic resonance imaging (MRI) has been proposed for tracking the progression of Alzheimer's disease (AD) through the assessment of brain atrophy. Detection of brain atrophy patterns in patients with AD as the longitudinal disease tracker. We used a refined version of orthonormal...