Naftopidil, a Novel α1-Adrenoceptor Antagonist, Displays Selective Inhibition of Canine Prostatic Pressure and High Affinity Binding to Cloned Human α1-Adrenoceptors

• Published in: Japanese journal of pharmacology Vol. 79; no. 4; pp. 447 - 454
• Main Authors: Ryo-ich, Takei, Ichiro, Ikegaki, Katsushi, Shibata, Gozoh, Tsujimoto, Toshio, Asano
• Format: Journal Article
• Language: English
• Published: The Japanese Pharmacological Society 1999
• Subjects: Anesthetized dog; Benign prostatic hyperplasia; Naftopidil; Prostate pressure; α1-Adrenoceptor antagonist; Benign prostatic hyperplasia; α1-Adrenoceptor antagonist; Prostate pressure; Anesthetized dog; Naftopidil

The pharmacological profiles of the α1-adrenoceptor antagonists naftopidil, tamsulosin and prazosin were studied in an anesthetized dog model that allowed the simultaneous assessment of their antagonist potency against phenylephrine-mediated increases in prostatic pressure and mean blood pressure. T...