E7HPV16 Oncogene and 17beta‐Estradiol Stress, Promotes Oncogenic microRNA Expression Patterns, Cell Proliferation and Cervical Intraepithelial Neoplasia 1

• Published in: Cell biochemistry and function Vol. 43; no. 3; pp. e70065 - n/a
• Main Authors: Arvizu‐Hernandez, Erandi, Ocadiz‐Delgado, Rodolfo, Gariglio, Patricio
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.03.2025
• Subjects: Animals; Cell Proliferation - drug effects; CIN 1; Estradiol - pharmacology; Female; Gene Expression Regulation, Neoplastic - drug effects; HPV; Human papillomavirus 16 - genetics; Humans; Kcnma1; Mice; MicroRNAs - genetics; MicroRNAs - metabolism; miR‐21; miR‐218; Papillomavirus E7 Proteins - genetics; Papillomavirus E7 Proteins - metabolism; Uterine Cervical Dysplasia - genetics; Uterine Cervical Dysplasia - metabolism; Uterine Cervical Dysplasia - pathology; Uterine Cervical Dysplasia - virology; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - metabolism; Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - virology; CIN 1; miR‐218; miR‐21; Kcnma1; HPV

ABSTRACT Cervical cancer (CC) is the second cause of death by a neoplasia in woman in Mexico. Among the factors that contribute to its development are prolonged infection by a high‐risk HPV type and the use of estrogens. It is well known that diagnosis at early stages is extremely important since, i...