The Alzheimer’s Disease Cooperative Study – Activities of Daily Living dependence score: revision and validation of an algorithm evaluating patient dependence across the spectrum of AD severity

• Published in: Journal of Prevention of Alzheimer's Disease, The Vol. 12; no. 8; p. 100261
• Main Authors: Chandler, Julie M., Lansdall, Claire J., Ye, Wenyu, McDougall, Fiona, Belger, Mark, Toth, Balazs, Mi, Xiaojuan, Sink, Kaycee M., Atkins, Alexandra S.
• Format: Journal Article
• Language: English
• Published: Elsevier Masson SAS 01.09.2025
• Subjects: Activities of Daily Living; Aged; Aged, 80 and over; Algorithms; Alzheimer Disease - diagnosis; Alzheimer Disease - psychology; Alzheimer’s disease; Alzheimer’s Disease Cooperative Study-Activities of Daily Living scale; Care partner; Caregivers; Cognitive Dysfunction; Dependence; Female; Humans; Male; Neurology; Severity of Illness Index; Alzheimer’s Disease Cooperative Study-Activities of Daily Living scale; Alzheimer’s disease; Care partner; Dependence

Increasing dependence on informal and formal caregivers in Alzheimer’s disease (AD) contributes to high societal cost. Treatments that delay time to increased dependence/care needs would be clinically meaningful, but these outcomes are rarely collected in early AD clinical trials. The 2015 ADCS-ADL...