Vδ2 T cell subsets, defined by PD-1 and TIM-3 expression, present varied cytokine responses in acute myeloid leukemia patients

• Published in: International immunopharmacology Vol. 80; p. 106122
• Main Authors: Wu, Kangni, Feng, Juan, Xiu, Yanghui, Li, Zhifeng, Lin, Zhijuan, Zhao, Haijun, Zeng, Hanyan, Xia, Weilin, Yu, Lian, Xu, Bing
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2020; Elsevier BV
• Subjects: Acute myeloid leukemia; Adult; Antibodies; Blocking antibodies; Cytokines; Female; Hepatitis A Virus Cellular Receptor 2 - immunology; Humans; Impact prediction; Inflammation; Interferon-gamma - genetics; Interferon-gamma - immunology; Interleukin 2; Intraepithelial Lymphocytes - immunology; Leukemia; Leukemia, Myeloid, Acute - immunology; Lymphocytes; Lymphocytes T; Male; Middle Aged; Myeloid leukemia; PD-1; PD-1 protein; PD-L1 protein; Programmed Cell Death 1 Receptor - immunology; Stem cell transplantation; Stem cells; TIM-3; Transplantation; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - immunology; Tumor necrosis factor-α; Vδ2 T cell; γ-Interferon; Vδ2 T cell; TIM-3; PD-1; Acute myeloid leukemia

•The levels of PD-1+TIM-3+ Vδ2 T cells were significantly higher in AML patients.•PD-1+TIM-3− subset presented the highest TNF-α and IFN-γ expression.•PD-1+TIM-3+ subset presented the lowest TNF-α and IFN-γ expression.•Anti-TIM-3 inhibition and anti-PD-1/TIM-3 dual inhibition elevated TNF-α and IFN-...