SDCBP/Syntenin-1 stabilizes BACH1 by disassembling the SCFFBXO22–BACH1 complex in triple-negative breast cancer

• Published in: The EMBO journal Vol. 44; no. 11; pp. 3085 - 3120
• Main Authors: Tran, Phi-Long, Kim, Okhwa, Hwangbo, Cheol, Kim, Hyo-Jin, Kim, Young-Myeong, Lee, Jeong-Hyung
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.04.2025
• Subjects: Biomedical and Life Sciences; EMBO03; EMBO37; Life Sciences; SDCBP; Ubiquitin E3 Ligase SCF; Metformin; Triple-negative Breast Cancer; BACH1

BACH1 is a redox-sensitive transcription factor facilitating tumor progression in triple-negative breast cancer (TNBC). However, the molecular mechanisms regulating BACH1 function in TNBC remain unclear. In this study, we demonstrate that SDCBP, a tandem-PDZ-domain protein, stabilizes BACH1 by disas...