Antibodies against the COOH-terminal region of E. coli ClpP protease in patients with primary biliary cirrhosis

• Published in: Journal of hepatology Vol. 33; no. 4; pp. 528 - 536
• Main Authors: Mayo, Isabel, Arizti, Paz, Parés, Albert, Oliva, Joaquín, Doforno, Rita Alvarez, Sagarra, Maria Rosa de, Rodés, Juan, Castaño, José G
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier B.V 01.10.2000; Elsevier
• Subjects: Adenosine Triphosphatases - chemistry; Adenosine Triphosphatases - immunology; Amino Acid Sequence; Antibodies; Antibodies, Bacterial - blood; Antibody Specificity; Autoimmune; Autoimmune Diseases - blood; Autoimmune Diseases - immunology; Biological and medical sciences; ClpP; Cysteine Endopeptidases - immunology; Digestive system; Endopeptidase Clp; Epitope mapping; Epitopes - chemistry; Epitopes - immunology; Escherichia coli - enzymology; Escherichia coli - immunology; Female; Humans; Investigative techniques, diagnostic techniques (general aspects); Liver Cirrhosis, Biliary - blood; Liver Cirrhosis, Biliary - immunology; Liver Diseases - blood; Liver Diseases - immunology; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - immunology; Male; Medical sciences; Middle Aged; Molecular Sequence Data; Multienzyme Complexes - immunology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Primary biliary cirrhosis; Proteasome; Proteasome Endopeptidase Complex; Reference Values; Sensitivity and Specificity; Serine Endopeptidases - chemistry; Serine Endopeptidases - immunology; Antibodies; Epitope mapping; Primary biliary cirrhosis; ClpP; Autoimmune; Proteasome; Autoimmunity; Human; Immunopathology; Antigenic determinant; Antibody; Escherichia coli; Hepatic disease; Autoimmune disease; Biliary cirrhosis; Biliary tract disease; Medical screening; Infection; Primitive; Predisposition; Bacteriosis; Immunoblotting assay; Digestive diseases; Bacteria; Comparative study; Enterobacteriaceae

Background/Aims: The presence of antibodies in sera from patients with autoimmune diseases is an important tool for diagnosis and for providing insights into the mechanisms leading to autoimmunity. The aim of this study was to characterize new reactive antigens in liver autoimmune diseases. Methods:...