Effect of the combined binding of topotecan and catechin/protocatechuic acid to a pH-sensitive DNA tetrahedron on release and cytotoxicity: Spectroscopic and calorimetric studies

• Published in: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Vol. 314; p. 124179
• Main Authors: Wang, Lu, Liu, Jie, Wang, Xiangtai, Li, Xinyu, Zhang, Xinpeng, Yuan, Lixia, Wu, Yushu, Liu, Min
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 05.06.2024
• Subjects: Chemotherapy drug; Combination therapy; Interaction; Natural polyphenol; pH-sensitive DNA tetrahedron; Chemotherapy drug; Combination therapy; Interaction; Natural polyphenol; pH-sensitive DNA tetrahedron

[Display omitted] •A pH-sensitive DNA tetrahedron (MUC1-TD) was used to co-deliver TPT and CAT/PCA.•The presence of CAT or PCA weakened the binding of TPT to MUC1-TD.•Acid pH and CAT/PCA, especially PCA, improved the release of TPT loaded by MUC1-TD.•CAT enhanced the cytotoxicity of TPT loaded by MU...