Pristimerin exhibits anti-cancer activity by inducing ER stress and AKT/GSK3β pathway through increasing intracellular ROS production in human esophageal cancer cells

• Published in: Toxicology in vitro Vol. 99; p. 105867
• Main Authors: Hu, Wei-Bin, Liu, Yi-Ting, Li, Jing, Wang, Ying, Sun, Xuan-Zi, Hua, Ming-Yu, Liu, Xue-Ting, Hui, Bei-Na
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2024
• Subjects: AKT/GSK3β; ER stress; Esophageal cancer; Pristimerin; ROS; ER stress; Pristimerin; Esophageal cancer; ROS; AKT/GSK3β

Pristimerin (Pris), a bioactive triterpenoid compound extracted from the Celastraceae and Hippocrateaceae families, has been reported to exhibit an anti-cancer property on various cancers. However, the effects of Pris on esophageal cancer are poorly investigated. This current study sought to explore...