Semi-automated assessment of the principal diffusion direction in the corpus callosum: differentiation of idiopathic normal pressure hydrocephalus from neurodegenerative diseases

• Published in: Journal of neurology Vol. 269; no. 4; pp. 1978 - 1988
• Main Authors: Caligiuri, Maria Eugenia, Quattrone, Andrea, Mechelli, Alessandro, La Torre, Domenico, Quattrone, Aldo
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2022; Springer Nature B.V
• Subjects: Alzheimer's disease; Anisotropy; Automation; Corpus callosum; Corpus Callosum - diagnostic imaging; Diffusion Tensor Imaging - methods; Humans; Hydrocephalus; Hydrocephalus, Normal Pressure - diagnostic imaging; Magnetic Resonance Imaging; Medicine; Medicine & Public Health; Neurodegenerative diseases; Neurodegenerative Diseases - diagnostic imaging; Neurology; Neuroradiology; Neurosciences; Original Communication; Paralysis; Patients; Progressive supranuclear palsy; Spatial distribution; Principal diffusion direction; Alzheimer’s disease; Progressive supranuclear palsy; Corpus callosum; Diffusion tensor imaging; Idiopathic normal pressure hydrocephalus

Background Idiopathic normal pressure hydrocephalus (iNPH) shares clinical and radiological features with progressive supranuclear palsy (PSP) and Alzheimer’s disease (AD). Corpus callosum (CC) involvement in these disorders is well established on structural MRI and diffusion tensor imaging (DTI), b...