Conformational analysis and biological activity of leptocarpin and leptocarpin acetate

This paper deals with the conformational study in solution of leptocarpin, a germacranolide with the heliangolide structure isolated from Leptocarpha rivularis D.C. The results obtained agree with the single crystal X-ray diffraction studies. Leptocarpin and leptocarpin acetate show 50% inhibition o...

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Bibliographic Details
Published inPlanta medica Vol. 61; no. 2; p. 188
Main Authors Martinez, R, Kesternich, V, Gutierrez, E, Doelz, H, Mansilla, H. (Universidad Austral de Chile, Valdivia (Chile). Inst. de Quimica)
Format Journal Article
LanguageEnglish
Published Germany 01.04.1995
Subjects
4-Butyrolactone - analogs & derivatives
4-Butyrolactone - chemistry
4-Butyrolactone - pharmacology
BIOCHIMIE
BIOQUIMICA
Carbohydrate Conformation
COMPOSICION QUIMICA
COMPOSITAE
COMPOSITION CHIMIQUE
ESTRUCTURA QUIMICA
FARMACOLOGIA
FEUILLE
germacranolide
HeLa Cells
HOJAS
Humans
LACTONAS
LACTONE
Leptocarpha rivularis
Magnetic Resonance Spectroscopy
METHIONINE
methionine uptake
METIONINA
Pflanzenbau
PHARMACOLOGIE
PLANTAS MEDICINALES
PLANTE MEDICINALE
Plants, Medicinal - chemistry
Sesquiterpenes - chemistry
Sesquiterpenes - pharmacology
SESQUITERPENOIDE
SESQUITERPENOS
STRUCTURE CHIMIQUE
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Summary:This paper deals with the conformational study in solution of leptocarpin, a germacranolide with the heliangolide structure isolated from Leptocarpha rivularis D.C. The results obtained agree with the single crystal X-ray diffraction studies. Leptocarpin and leptocarpin acetate show 50% inhibition of (35 S)-methionine uptake without affecting the (methyl-3H)thymidine and (5.6-3H)uridine incorporation, when assayed in HeLa cells.
Bibliography:F60
97B5804
ISSN:0032-0943
1439-0221
DOI:10.1055/s-2006-958048