A randomized, double-blinded, placebo-controlled pilot trial of anticoagulation in low-risk traumatic brain injury: The Delayed Versus Early Enoxaparin Prophylaxis I (DEEP I) study

• Published in: The journal of trauma and acute care surgery Vol. 73; no. 6; p. 1434
• Main Authors: Phelan, Herb A, Wolf, Steven E, Norwood, Scott H, Aldy, Kim, Brakenridge, Scott C, Eastman, Alexander L, Madden, Christopher J, Nakonezny, Paul A, Yang, Lisa, Chason, David P, Arbique, Gary M, Berne, John, Minei, Joseph P
• Format: Journal Article
• Language: English
• Published: United States 01.12.2012
• Subjects: Adult; Anticoagulants - administration & dosage; Anticoagulants - therapeutic use; Brain Injuries - diagnostic imaging; Brain Injuries - drug therapy; Double-Blind Method; Enoxaparin - administration & dosage; Enoxaparin - therapeutic use; Female; Humans; Intracranial Hemorrhages - drug therapy; Male; Neuroimaging; Pilot Projects; Tomography, X-Ray Computed; Venous Thromboembolism - prevention & control

Our group has created an algorithm for venous thromboembolism prophylaxis after traumatic brain injury (TBI), which stratifies patients into low, moderate, and high risk for spontaneous injury progression and tailors a prophylaxis regimen to each arm. We present the results of the Delayed Versus Ear...