Subtype-selective effect and molecular regulation of celastrol and triptolide at human nicotinic acetylcholine receptors

• Published in: Chemico-biological interactions Vol. 408; p. 111412
• Main Authors: Moon, Myungmi, Pyeon, Minsu, Yang, Jaehui, Yun, Jeongyeon, Yeom, Hye Duck, Lee, Mee-Hyun, Lee, Gihyun, Lee, Junho H.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 25.02.2025
• Subjects: Binding Sites; Celastrol; Diterpenes - chemistry; Diterpenes - metabolism; Diterpenes - pharmacology; Epoxy Compounds - chemistry; Epoxy Compounds - metabolism; Epoxy Compounds - pharmacology; Humans; Molecular Docking Simulation; Mutation; Nicotinic acetylcholine receptors; Pentacyclic Triterpenes; Phenanthrenes - chemistry; Phenanthrenes - metabolism; Phenanthrenes - pharmacology; Receptors, Nicotinic - chemistry; Receptors, Nicotinic - genetics; Receptors, Nicotinic - metabolism; Subtype-specific effect; Tripterygium - chemistry; Triptolide; Triterpenes - chemistry; Triterpenes - metabolism; Triterpenes - pharmacology; Celastrol; Triptolide; Nicotinic acetylcholine receptors; Subtype-specific effect

Celastrol and triptolide, bioactive compounds isolated from Tripterygium wilfordii Hook F, have demonstrated significant pharmacological effects across various biological pathways, making them subjects of extensive research for potential therapeutic applications. Celastrol and triptolide are known t...