A comprehensive method to analyze single-cell vibrations

• Published in: Biophysical journal Vol. 124; no. 1; pp. 77 - 92
• Main Authors: Al-Khaz’Aly, Ali, Ghandorah, Salim, Topham, Jared J., Osman, Nasir, Louie, Taye, Farshidfar, Farshad, Amrein, Matthias
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.01.2025
• Subjects: Cell Line, Tumor; Humans; Optical Tweezers; Principal Component Analysis; Single-Cell Analysis - methods; Vibration

All living cells vibrate depending on metabolism. It has been hypothesized that vibrations are unique for a given phenotype and thereby suitable to diagnose cancer type and stage and to pre-assess the effectiveness of pharmaceutical treatments in real time. However, cells exhibit highly variable vib...