Middle-age abolishes cardioprotection conferred by thioredoxin-1 in mice

• Published in: Archives of biochemistry and biophysics Vol. 753; p. 109880
• Main Authors: Perez, V., Zaobornyj, T., Vico, T., Vanasco, V., Marchini, T., Godoy, E., Alvarez, S., Evelson, P., Donato, M., Gelpi, R.J., D'Annunzio, V.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2024
• Subjects: Hydrogen peroxide production; Ischemia/reperfusion injury; Ischemic postconditioning; Mitochondrial bioenergetics; Trx1 overexpression; Ischemia/reperfusion injury; Ischemic postconditioning; Trx1 overexpression; Mitochondrial bioenergetics; Hydrogen peroxide production

Thioredoxin-1 (Trx1) has cardioprotective effects on ischemia/reperfusion (I/R) injury, although its role in ischemic postconditioning (PostC) in middle-aged mice is not understood. This study aimed to evaluate if combining two cardioprotective strategies, such as Trx1 overexpression and PostC, coul...