The hippocampal salt-inducible kinase 2-CREB-regulated transcription co-activator 1 system mediates the antidepressant actions of paroxetine in mice

• Published in: Behavioural brain research Vol. 465; p. 114972
• Main Authors: Cai, Xiang-Ming, Sun, Xiao-Yu, Li, Rui, Wang, Pei-Juan, Qiu, Jian-Cheng, Ge, Yu-Xin, Yang, Lei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 08.05.2024
• Subjects: Animals; Antidepressive Agents - pharmacology; Chronic social defeat stress; Chronic unpredictable mild stress; CREB-regulated transcription co-activator 1; Depression; Fluoxetine - pharmacology; Hippocampus - metabolism; Mice; Paroxetine; Paroxetine - pharmacology; Salt-inducible kinase 2; Serotonin - metabolism; CSDS; Paroxetine; CRTC1; FST; CUMS; Depression; Co-IP; Chronic unpredictable mild stress; MDD; SSRI; ShRNA; CREB; TST; ANOVA; AAV; Chronic social defeat stress; Salt-inducible kinase 2; SEM; SIK2; 5-HT; QRT-PCR; CREB-regulated transcription co-activator 1

The hippocampal salt-inducible kinase 2 (SIK2)-CREB-regulated transcription co-activator 1 (CRTC1) system has been demonstrated to participate in not only the pathogenesis of depression but also the antidepressant mechanisms of several antidepressant medications including fluoxetine, paroxetine, and...