Activation of GSDMD contributes to acute kidney injury induced by cisplatin

• Published in: American journal of physiology. Renal physiology Vol. 318; no. 1; pp. F96 - F106
• Main Authors: Li, Yuanyuan, Xia, Weiwei, Wu, Mengying, Yin, Jie, Wang, Qian, Li, Shuzhen, Zhang, Aihua, Huang, Songming, Zhang, Yue, Jia, Zhanjun
• Format: Journal Article
• Language: English
• Published: United States 01.01.2020
• Subjects: Acute Kidney Injury - chemically induced; Acute Kidney Injury - metabolism; Acute Kidney Injury - pathology; Animals; Antineoplastic Agents - adverse effects; Cisplatin - adverse effects; Inflammation - chemically induced; Inflammation - metabolism; Inflammation - pathology; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Kidney - metabolism; Kidney - pathology; Male; Mice; Mice, Knockout; Phosphate-Binding Proteins - genetics; Phosphate-Binding Proteins - metabolism; Pyroptosis - physiology; pyroptosis; acute kidney injury; cisplatin; inflammation; GSDMD-N

Cisplatin is one of the most effective antitumor agents, but its clinical use is highly limited by its severe side effects, especially nephrotoxicity. Recently, the active form of gasdermin D (GSDMD), termed GSDMD-N, was identified to mediate pyroptotic inflammatory cell death in several diseases. H...