Antineoplastic properties of bacteriocins: revisiting potential active agents

Bacteriocins are antimicrobial peptides produced by a wide range of bacteria. Their antineoplastic properties have been inadequately revealed in the late 70s by using crude bacteriocin preparation toxic to mammalian cells. Nowadays, purified bacteriocins are available and have shown inhibitory prope...

Full description

Saved in:
Bibliographic Details
Published inAmerican journal of clinical oncology Vol. 31; no. 4; p. 399
Main Authors Cornut, Gilbert, Fortin, Claude, Soulières, Denis
Format Journal Article
LanguageEnglish
Published United States 01.08.2008
Subjects
Animals
Anti-Bacterial Agents - therapeutic use
Antineoplastic Agents - therapeutic use
Bacteriocins - therapeutic use
Humans
Neoplasms - drug therapy
Online AccessGet more information

Cover

More Information
Summary:Bacteriocins are antimicrobial peptides produced by a wide range of bacteria. Their antineoplastic properties have been inadequately revealed in the late 70s by using crude bacteriocin preparation toxic to mammalian cells. Nowadays, purified bacteriocins are available and have shown inhibitory properties toward diverse neoplastic line cells. Pyocin, colicin, pediocin, and microcin are among bacteriocins reported to present such activity. Moreover, modified bacteriocins proved to be effective in a glioblastoma xenograft mouse model. Screening for the presence of bacteriocin in colon cancer subjects has been studied with mixed results. Bacteriocin use as a therapeutic agent or in a prevention setting is discussed specifically evaluating bacteriocins biochemical properties and recent advances in peptide therapeutics.
ISSN:1537-453X
DOI:10.1097/COC.0b013e31815e456d