The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is an independent prognostic marker in patients with malignant glioma

The lncRNA has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of in glioma, the most common primary brain tumors, and its clinical relevance. gene expression, methylation, copy-number and prognostic value were investigated in...

Full description

Saved in:
Bibliographic Details
Published inOncotarget Vol. 9; no. 21; pp. 15740 - 15756
Main Authors Xavier-Magalhães, Ana, Gonçalves, Céline S, Fogli, Anne, Lourenço, Tatiana, Pojo, Marta, Pereira, Bruno, Rocha, Miguel, Lopes, Maria Celeste, Crespo, Inês, Rebelo, Olinda, Tão, Herminio, Lima, João, Moreira, Ricardo, Pinto, Afonso A, Jones, Chris, Reis, Rui M, Costello, Joseph F, Arnaud, Philippe, Sousa, Nuno, Costa, Bruno M
Format Journal Article
LanguageEnglish
Published United States Impact journals 20.03.2018
Impact Journals LLC
Subjects
Biochemistry, Molecular Biology
Cancer
Genomics
Life Sciences
Molecular biology
Molecular Networks
Research Paper
HOTAIR
glioma
HOXA9
glioblastoma
prognosis
Online AccessGet full text

Cover

Abstract The lncRNA has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of in glioma, the most common primary brain tumors, and its clinical relevance. gene expression, methylation, copy-number and prognostic value were investigated in human gliomas integrating data from online datasets and our cohorts. High levels of were associated with higher grades of glioma, particularly IDH wild-type cases. Mechanistically, was overexpressed in a gene dosage-independent manner, while DNA methylation levels of particular CpGs in locus were associated with expression levels in GBM clinical specimens and cell lines. Concordantly, the demethylating agent 5-Aza-2'-deoxycytidine affected transcriptional levels in a cell line-dependent manner. Importantly, was frequently co-expressed with in high-grade gliomas from TCGA, Oncomine, and our Portuguese and French datasets. Integrated analyses, chromatin immunoprecipitation, and qPCR data showed that HOXA9 binds directly to the promoter of . Clinically, GBM patients with high expression had a significantly reduced overall survival, independently of other prognostic variables. In summary, this work reveals as a novel direct regulator of , and establishes as an independent prognostic marker, providing new therapeutic opportunities to treat this highly aggressive cancer.
AbstractList The lncRNA HOTAIR has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of HOTAIR in glioma, the most common primary brain tumors, and its clinical relevance. HOTAIR gene expression, methylation, copy-number and prognostic value were investigated in human gliomas integrating data from online datasets and our cohorts. High levels of HOTAIR were associated with higher grades of glioma, particularly IDH wild-type cases. Mechanistically, HOTAIR was overexpressed in a gene dosage-independent manner, while DNA methylation levels of particular CpGs in HOTAIR locus were associated with HOTAIR expression levels in GBM clinical specimens and cell lines. Concordantly, the demethylating agent 5-Aza-2′-deoxycytidine affected HOTAIR transcriptional levels in a cell line-dependent manner. Importantly, HOTAIR was frequently co-expressed with HOXA9 in high-grade gliomas from TCGA, Oncomine, and our Portuguese and French datasets. Integrated in silico analyses, chromatin immunoprecipitation, and qPCR data showed that HOXA9 binds directly to the promoter of HOTAIR. Clinically, GBM patients with high HOTAIR expression had a significantly reduced overall survival, independently of other prognostic variables. In summary, this work reveals HOXA9 as a novel direct regulator of HOTAIR, and establishes HOTAIR as an independent prognostic marker, providing new therapeutic opportunities to treat this highly aggressive cancer.
The lncRNA has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of in glioma, the most common primary brain tumors, and its clinical relevance. gene expression, methylation, copy-number and prognostic value were investigated in human gliomas integrating data from online datasets and our cohorts. High levels of were associated with higher grades of glioma, particularly IDH wild-type cases. Mechanistically, was overexpressed in a gene dosage-independent manner, while DNA methylation levels of particular CpGs in locus were associated with expression levels in GBM clinical specimens and cell lines. Concordantly, the demethylating agent 5-Aza-2'-deoxycytidine affected transcriptional levels in a cell line-dependent manner. Importantly, was frequently co-expressed with in high-grade gliomas from TCGA, Oncomine, and our Portuguese and French datasets. Integrated analyses, chromatin immunoprecipitation, and qPCR data showed that HOXA9 binds directly to the promoter of . Clinically, GBM patients with high expression had a significantly reduced overall survival, independently of other prognostic variables. In summary, this work reveals as a novel direct regulator of , and establishes as an independent prognostic marker, providing new therapeutic opportunities to treat this highly aggressive cancer.
The lncRNA HOTAIR has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of HOTAIR in glioma, the most common primary brain tumors, and its clinical relevance. HOTAIR gene expression, methylation, copy-number and prognostic value were investigated in human gliomas integrating data from online datasets and our cohorts. High levels of HOTAIR were associated with higher grades of glioma, particularly IDH wild-type cases. Mechanistically, HOTAIR was overexpressed in a gene dosage-independent manner, while DNA methylation levels of particular CpGs in HOTAIR locus were associated with HOTAIR expression levels in GBM clinical specimens and cell lines. Concordantly, the demethylating agent 5-Aza-2′-deoxycytidine affected HOTAIR transcriptional levels in a cell line-dependent manner. Importantly, HOTAIR was frequently co-expressed with HOXA9 in high-grade gliomas from TCGA, Oncomine, and our Portuguese and French datasets. Integrated in silico analyses, chromatin immunoprecipitation, and qPCR data showed that HOXA9 binds directly to the promoter of HOTAIR . Clinically, GBM patients with high HOTAIR expression had a significantly reduced overall survival, independently of other prognostic variables. In summary, this work reveals HOXA9 as a novel direct regulator of HOTAIR , and establishes HOTAIR as an independent prognostic marker, providing new therapeutic opportunities to treat this highly aggressive cancer.
Author Gonçalves, Céline S
Crespo, Inês
Rebelo, Olinda
Lima, João
Costello, Joseph F
Pereira, Bruno
Moreira, Ricardo
Pinto, Afonso A
Arnaud, Philippe
Costa, Bruno M
Sousa, Nuno
Rocha, Miguel
Lopes, Maria Celeste
Tão, Herminio
Jones, Chris
Lourenço, Tatiana
Xavier-Magalhães, Ana
Pojo, Marta
Reis, Rui M
Fogli, Anne
Author_xml – sequence: 1
  givenname: Ana
  surname: Xavier-Magalhães
  fullname: Xavier-Magalhães, Ana
  organization: ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Braga, Portugal
– sequence: 2
  givenname: Céline S
  surname: Gonçalves
  fullname: Gonçalves, Céline S
  organization: ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Braga, Portugal
– sequence: 3
  givenname: Anne
  surname: Fogli
  fullname: Fogli, Anne
  organization: Biochemistry and Molecular Biology Department, Clermont-Ferrand Hospital, Clermont-Ferrand, France
– sequence: 4
  givenname: Tatiana
  surname: Lourenço
  fullname: Lourenço, Tatiana
  organization: ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Braga, Portugal
– sequence: 5
  givenname: Marta
  surname: Pojo
  fullname: Pojo, Marta
  organization: ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Braga, Portugal
– sequence: 6
  givenname: Bruno
  surname: Pereira
  fullname: Pereira, Bruno
  organization: Biostatistics Department, DRCI, Clermont-Ferrand Hospital, Clermont-Ferrand, France
– sequence: 7
  givenname: Miguel
  surname: Rocha
  fullname: Rocha, Miguel
  organization: Centre of Biological Engineering, School of Engineering, University of Minho, Campus de Gualtar, Braga, Portugal
– sequence: 8
  givenname: Maria Celeste
  surname: Lopes
  fullname: Lopes, Maria Celeste
  organization: Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
– sequence: 9
  givenname: Inês
  surname: Crespo
  fullname: Crespo, Inês
  organization: Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
– sequence: 10
  givenname: Olinda
  surname: Rebelo
  fullname: Rebelo, Olinda
  organization: Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
– sequence: 11
  givenname: Herminio
  surname: Tão
  fullname: Tão, Herminio
  organization: Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
– sequence: 12
  givenname: João
  surname: Lima
  fullname: Lima, João
  organization: Department of Neurosurgery, Hospital Escala Braga, Braga, Portugal
– sequence: 13
  givenname: Ricardo
  surname: Moreira
  fullname: Moreira, Ricardo
  organization: Department of Neurosurgery, Hospital Escala Braga, Braga, Portugal
– sequence: 14
  givenname: Afonso A
  surname: Pinto
  fullname: Pinto, Afonso A
  organization: Department of Neurosurgery, Hospital Escala Braga, Braga, Portugal
– sequence: 15
  givenname: Chris
  surname: Jones
  fullname: Jones, Chris
  organization: Divisions of Molecular Pathology and Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey, United Kingdom
– sequence: 16
  givenname: Rui M
  surname: Reis
  fullname: Reis, Rui M
  organization: Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil
– sequence: 17
  givenname: Joseph F
  surname: Costello
  fullname: Costello, Joseph F
  organization: Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA
– sequence: 18
  givenname: Philippe
  surname: Arnaud
  fullname: Arnaud, Philippe
  organization: GReD, Université Clermont Auvergne, CNRS, INSERM, Clermont-Ferrand, France
– sequence: 19
  givenname: Nuno
  surname: Sousa
  fullname: Sousa, Nuno
  organization: ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Braga, Portugal
– sequence: 20
  givenname: Bruno M
  surname: Costa
  fullname: Costa, Bruno M
  organization: ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Braga, Portugal
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29644006$$D View this record in MEDLINE/PubMed
https://uca.hal.science/hal-01917288$$DView record in HAL
BookMark eNpdkdFuFCEUhompsbX2AbwxXOrFVGBggBuTSVPdJhubNGviHWEYZhadhRHYNfsWPrJst9YqF3Byznf-c8j_Epz44C0ArzG6xKKpyfvgTcg6jjZfEsokfwbOsKSyIozVJ0_iU3CR0jdUDqNcEPkCnBLZUIpQcwZ-rdYWTsGPsMhXJvSuhHefW7i4XbU3d9AlmKP2yUQ3Zxe8nqY91Ca7nc62h92-gF9bCbXvD6z20PnezrZcPsM5htGHlJ2BGx2_21iqcNbZlWKCP11el_zkRq8LPE4ubPQr8HzQU7IXD-85-PLxenW1qJa3n26u2mVlasRyxQTngyCWkH7oOEPEippaRg2S2pCBGFY3TBZCdEYOvdEdlzUaJJOEYSRIfQ4-HHXnbbexvSkbRT2pObqy6V4F7dS_Fe_Wagw7xYSgTYOLwLujwPq_tkW7VIccwhJzIsTuwL59GBbDj61NWW1cMnaatLdhmxRBhFLOa0ILio-oiSGlaIdHbYzUvfHqr_Hq3vjS8-bpXx47_thc_wZtGK9-
CitedBy_id crossref_primary_10_1016_j_omtn_2021_07_024
crossref_primary_10_1016_j_ncrna_2024_02_002
crossref_primary_10_1007_s10571_024_01455_8
crossref_primary_10_1016_j_heliyon_2024_e24799
crossref_primary_10_1016_j_heliyon_2021_e06502
crossref_primary_10_3390_cancers16020434
crossref_primary_10_1038_s41388_021_01743_3
crossref_primary_10_1111_jcmm_15233
crossref_primary_10_1007_s10238_024_01389_x
crossref_primary_10_1016_j_intimp_2020_106842
crossref_primary_10_3389_fonc_2018_00521
crossref_primary_10_1007_s11011_022_01099_x
crossref_primary_10_1021_acs_molpharmaceut_0c00709
crossref_primary_10_3389_fonc_2021_712786
crossref_primary_10_1002_1878_0261_12633
crossref_primary_10_1007_s00109_020_01984_x
crossref_primary_10_1007_s00018_020_03508_9
crossref_primary_10_1016_j_thromres_2020_04_039
crossref_primary_10_1007_s10555_023_10159_2
crossref_primary_10_1016_j_cca_2019_12_028
crossref_primary_10_1186_s12935_022_02767_9
crossref_primary_10_3390_ijms23094743
crossref_primary_10_1016_j_canlet_2019_04_016
crossref_primary_10_1016_j_dnarep_2021_103141
crossref_primary_10_1007_s11011_023_01234_2
crossref_primary_10_1017_erm_2024_11
crossref_primary_10_3390_cancers12071842
crossref_primary_10_1007_s12672_024_01077_y
crossref_primary_10_1186_s43042_023_00404_2
Cites_doi 10.3892/ol.2016.4743
10.1038/nature07385
10.1016/j.ccr.2006.03.003
10.18632/oncotarget.4290
10.1371/journal.pone.0005209
10.1371/journal.pone.0070372
10.1073/pnas.1424220112
10.1158/0008-5472.CAN-09-2189
10.1016/j.gdata.2015.05.010
10.1073/pnas.0904715106
10.1158/0008-5472.CAN-10-1250
10.3892/mmr.2015.4161
10.1007/s11060-016-2345-0
10.1073/pnas.0706729105
10.1038/nprot.2006.27
10.1038/nature09165
10.1093/nar/23.23.4878
10.1038/nrg2521
10.1212/01.wnl.0000339055.64476.cb
10.1007/s11060-011-0793-0
10.1002/sim.4509
10.3892/ijo.2017.3901
10.18632/oncotarget.8895
10.1016/j.ejca.2010.11.031
10.1016/j.molmed.2011.01.011
10.1593/neo.07112
10.1126/science.1192002
10.1128/mBio.00558-12
10.1016/S0021-9258(17)37680-9
10.1093/neuonc/not131
10.1200/JCO.2007.15.7164
10.1016/j.ccell.2017.06.003
10.1101/gad.1524107
10.1002/glia.21136
10.1016/j.cell.2007.05.022
10.1016/j.bbcan.2015.07.001
10.1159/000369732
10.1093/bioinformatics/bti473
10.1002/ana.22425
10.1186/1476-4598-10-38
10.1093/hmg/ddq353
10.1038/nature08975
10.1172/JCI39534
10.1038/nm.2661
10.1006/meth.2001.1262
10.1016/j.ccr.2006.02.019
10.1097/WNR.0000000000000717
10.1038/nsmb840
10.1016/j.bmcl.2007.02.032
10.2217/fon.11.102
10.18632/oncotarget.2681
10.7497/j.issn.2095-3941.2015.0006
10.18632/oncotarget.3229
10.1002/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3
10.18632/oncotarget.3150
10.1016/j.cell.2009.02.006
10.1158/0008-5472.CAN-04-0452
10.1016/j.jnci.2013.11.001
10.1038/emboj.2013.95
ContentType Journal Article
Copyright Distributed under a Creative Commons Attribution 4.0 International License
Copyright: © 2018 Xavier-Magalhães et al. 2018
Copyright_xml – notice: Distributed under a Creative Commons Attribution 4.0 International License
– notice: Copyright: © 2018 Xavier-Magalhães et al. 2018
DBID NPM
AAYXX
CITATION
7X8
1XC
VOOES
5PM
DOI 10.18632/oncotarget.24597
DatabaseName PubMed
CrossRef
MEDLINE - Academic
Hyper Article en Ligne (HAL)
Hyper Article en Ligne (HAL) (Open Access)
PubMed Central (Full Participant titles)
DatabaseTitle PubMed
CrossRef
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic
PubMed
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
EISSN 1949-2553
EndPage 15756
ExternalDocumentID oai_HAL_hal_01917288v1
10_18632_oncotarget_24597
29644006
Genre Journal Article
GroupedDBID ---
53G
ADBBV
ADRAZ
AENEX
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
DIK
FRJ
GX1
HYE
KQ8
M48
M~E
NPM
OK1
PGMZT
RPM
AAYXX
CITATION
7X8
1XC
VOOES
5PM
ID FETCH-LOGICAL-c305t-5877f82e22dfb7502e834e54c09ac2f2c53659f828bc9fdcab7930f9592510823
IEDL.DBID RPM
ISSN 1949-2553
IngestDate Tue Sep 17 21:16:04 EDT 2024
Thu Oct 10 06:48:38 EDT 2024
Fri Aug 16 00:49:45 EDT 2024
Fri Aug 23 01:32:06 EDT 2024
Tue Aug 27 13:46:09 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed false
IsScholarly true
Issue 21
Keywords HOTAIR
glioma
HOXA9
glioblastoma
prognosis
Language English
License Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0
This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c305t-5877f82e22dfb7502e834e54c09ac2f2c53659f828bc9fdcab7930f9592510823
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMCID: PMC5884661
These authors contributed equally to this work
ORCID 0000-0002-7141-9285
0000-0001-7336-2588
0000-0002-7937-8764
0000-0003-2344-2234
0000-0003-2655-7803
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884661/
PMID 29644006
PQID 2024477324
PQPubID 23479
PageCount 17
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_5884661
hal_primary_oai_HAL_hal_01917288v1
proquest_miscellaneous_2024477324
crossref_primary_10_18632_oncotarget_24597
pubmed_primary_29644006
PublicationCentury 2000
PublicationDate 2018-Mar-20
PublicationDateYYYYMMDD 2018-03-20
PublicationDate_xml – month: 03
  year: 2018
  text: 2018-Mar-20
  day: 20
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Oncotarget
PublicationTitleAlternate Oncotarget
PublicationYear 2018
Publisher Impact journals
Impact Journals LLC
Publisher_xml – name: Impact journals
– name: Impact Journals LLC
References Reis (56) 2009; 4
Cancer Genome Atlas Research Network (57) 2008; 455
Kang (16) 2013; 15
Pinto (42) 2017; 132
Werner (60) 1995; 23
Mandal (13) 2015; 1856
Wang (20) 2017
Groudine (34) 2004; 11
Dietrich (39) 2008; 26
Costello (38) 2010; 70
Costa (27) 2015; 5
Schmittgen (62) 2001; 25
Wahlestedt (44) 2015; 112
Kristie (51) 2013; 4
Fine (23) 2006; 9
Parker (48) 2007; 17
Chang (10) 2007; 129
Dietrich (21) 2008; 26
Cavenee (1) 2016
Kong (30) 2010; 464
Jones (40) 2010; 70
Leenstra (6) 2012; 108
Youden (64) 1950; 3
Feuerstein (24) 2006; 9
Lam (8) 2011; 10
Huang (46) 2015; 35
Riggins (3) 2011; 17
Xue (17) 2015; 6
Rinn (37) 2009; 106
Huang (35) 2013; 32
Rinn (11) 2010; 19
Mattick (43) 2008; 105
Stupp (2) 2011; 70
Zhao (32) 2016; 7
Salavaty (14) 2015; 12
Kettenmann (4) 2011; 59
Yang (31) 2015; 6
Chakravarti (5) 2011; 7
Chang (12) 2010; 329
Moneer (53) 2014; 26
Chinnaiyan (58) 2007; 9
Hajian-Tilaki (65) 2013; 4
Werner (59) 2005; 21
Li (15) 2015; 12
Weber (41) 2010; 120
Varhol (33) 2010; 466
Enokida (47) 2013; 8
Liu (63) 2012; 31
Bomsztyk (61) 2006; 1
Rocha (26) 2015; 6
Brown (49) 1994; 269
Yu (50) 2007; 21
Yang (19) 2015; 6
Lin (25) 2017; 32
Liu (45) 2017; 28
Tian (18) 2016; 12
Cancer Genome Atlas Research Network (36) 2008; 455
Costello (28) 2010; 70
Mattick (9) 2009; 10
Nelson (22) 2004; 64
Sanson (54) 2009; 72
Delattre (55) 2011; 47
Jones (29) 2010; 70
Woster (52) 2012; 18
Reik (7) 2009; 136
References_xml – volume: 12
  start-page: 879
  year: 2016
  ident: 18
  article-title: miR-148b-3p inhibits malignant biological behaviors of human glioma cells induced by high HOTAIR expression
  publication-title: Oncol Lett
  doi: 10.3892/ol.2016.4743
  contributor:
    fullname: Tian
– volume: 455
  start-page: 1061
  year: 2008
  ident: 36
  article-title: Comprehensive genomic characterization defines human glioblastoma genes and core pathways
  publication-title: Nature
  doi: 10.1038/nature07385
  contributor:
    fullname: Cancer Genome Atlas Research Network
– volume: 9
  start-page: 287
  year: 2006
  ident: 23
  article-title: Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2006.03.003
  contributor:
    fullname: Fine
– volume: 6
  start-page: 21934
  year: 2015
  ident: 17
  article-title: Knockdown of long non-coding RNA HOTAIR inhibits malignant biological behaviors of human glioma cells via modulation of miR-326
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.4290
  contributor:
    fullname: Xue
– volume: 4
  start-page: e5209
  year: 2009
  ident: 56
  article-title: Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development
  publication-title: PloS One
  doi: 10.1371/journal.pone.0005209
  contributor:
    fullname: Reis
– volume: 8
  start-page: e70372
  year: 2013
  ident: 47
  article-title: Genistein inhibits prostate cancer cell growth by targeting miR-34a and oncogenic HOTAIR.
  publication-title: PloS One
  doi: 10.1371/journal.pone.0070372
  contributor:
    fullname: Enokida
– volume: 112
  start-page: 8326
  year: 2015
  ident: 44
  article-title: The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1424220112
  contributor:
    fullname: Wahlestedt
– volume: 70
  start-page: 453
  year: 2010
  ident: 28
  article-title: Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma
  publication-title: Cancer research
  doi: 10.1158/0008-5472.CAN-09-2189
  contributor:
    fullname: Costello
– volume: 5
  start-page: 54
  year: 2015
  ident: 27
  article-title: Transcriptional profiling of HOXA9-regulated genes in human glioblastoma cell models
  publication-title: Genom Data
  doi: 10.1016/j.gdata.2015.05.010
  contributor:
    fullname: Costa
– volume: 106
  start-page: 11667
  year: 2009
  ident: 37
  article-title: Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0904715106
  contributor:
    fullname: Rinn
– volume: 70
  start-page: 9243
  year: 2010
  ident: 29
  article-title: MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature
  publication-title: Cancer research
  doi: 10.1158/0008-5472.CAN-10-1250
  contributor:
    fullname: Jones
– volume: 12
  start-page: 5611
  year: 2015
  ident: 15
  article-title: Long non-coding RNA HOTAIR: A novel oncogene (Review)
  publication-title: Mol Med Rep
  doi: 10.3892/mmr.2015.4161
  contributor:
    fullname: Li
– volume: 132
  start-page: 27
  year: 2017
  ident: 42
  article-title: Effects of the functional HOTAIR rs920778 and rs12826786 genetic variants in glioma susceptibility and patient prognosis
  publication-title: J Neurooncol
  doi: 10.1007/s11060-016-2345-0
  contributor:
    fullname: Pinto
– volume: 105
  start-page: 716
  year: 2008
  ident: 43
  article-title: Specific expression of long noncoding RNAs in the mouse brain
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0706729105
  contributor:
    fullname: Mattick
– volume: 1
  start-page: 179
  year: 2006
  ident: 61
  article-title: Protocol for the fast chromatin immunoprecipitation (ChIP) method
  publication-title: Nat Protoc
  doi: 10.1038/nprot.2006.27
  contributor:
    fullname: Bomsztyk
– volume: 466
  start-page: 253
  year: 2010
  ident: 33
  article-title: Conserved role of intragenic DNA methylation in regulating alternative promoters
  publication-title: Nature
  doi: 10.1038/nature09165
  contributor:
    fullname: Varhol
– volume: 23
  start-page: 4878
  year: 1995
  ident: 60
  article-title: MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/23.23.4878
  contributor:
    fullname: Werner
– volume: 10
  start-page: 155
  year: 2009
  ident: 9
  article-title: Long non-coding RNAs: insights into functions
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg2521
  contributor:
    fullname: Mattick
– volume: 72
  start-page: 156
  year: 2009
  ident: 54
  article-title: alpha-Internexin expression identifies 1p19q codeleted gliomas
  publication-title: Neurology
  doi: 10.1212/01.wnl.0000339055.64476.cb
  contributor:
    fullname: Sanson
– volume: 108
  start-page: 11
  year: 2012
  ident: 6
  article-title: Recent advances in the molecular understanding of glioblastoma
  publication-title: J Neurooncol
  doi: 10.1007/s11060-011-0793-0
  contributor:
    fullname: Leenstra
– volume: 31
  start-page: 2676
  year: 2012
  ident: 63
  article-title: Classification accuracy and cut point selection
  publication-title: Stat Med
  doi: 10.1002/sim.4509
  contributor:
    fullname: Liu
– year: 2017
  ident: 20
  article-title: HOTAIR upregulates an 18-gene cell cycle-related mRNA network in glioma
  publication-title: Int J Oncol
  doi: 10.3892/ijo.2017.3901
  contributor:
    fullname: Wang
– volume: 7
  start-page: 30610
  year: 2016
  ident: 32
  article-title: Epigenetic modification of miR-141 regulates SKA2 by an endogenous ‘sponge’ HOTAIR in glioma
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.8895
  contributor:
    fullname: Zhao
– volume: 47
  start-page: 802
  year: 2011
  ident: 55
  article-title: Diagnostic and prognostic value of alpha internexin expression in a series of 409 gliomas
  publication-title: Eur J Cancer
  doi: 10.1016/j.ejca.2010.11.031
  contributor:
    fullname: Delattre
– volume: 17
  start-page: 301
  year: 2011
  ident: 3
  article-title: Molecular targeting of glioblastoma: Drug discovery and therapies
  publication-title: Trends Mol Med
  doi: 10.1016/j.molmed.2011.01.011
  contributor:
    fullname: Riggins
– volume: 455
  start-page: 1061
  year: 2008
  ident: 57
  article-title: Comprehensive genomic characterization defines human glioblastoma genes and core pathways
  publication-title: Nature
  doi: 10.1038/nature07385
  contributor:
    fullname: Cancer Genome Atlas Research Network
– volume: 9
  start-page: 166
  year: 2007
  ident: 58
  article-title: Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles
  publication-title: Neoplasia
  doi: 10.1593/neo.07112
  contributor:
    fullname: Chinnaiyan
– volume: 329
  start-page: 689
  year: 2010
  ident: 12
  article-title: Long noncoding RNA as modular scaffold of histone modification complexes
  publication-title: Science
  doi: 10.1126/science.1192002
  contributor:
    fullname: Chang
– volume: 4
  start-page: e00558
  year: 2013
  ident: 51
  article-title: A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency
  publication-title: mBio
  doi: 10.1128/mBio.00558-12
  contributor:
    fullname: Kristie
– volume-title: World Health Organization Histological Classification of Tumours of the Central Nervous System
  year: 2016
  ident: 1
  contributor:
    fullname: Cavenee
– volume: 269
  start-page: 5241
  year: 1994
  ident: 49
  article-title: A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
  publication-title: The Journal of biological chemistry
  doi: 10.1016/S0021-9258(17)37680-9
  contributor:
    fullname: Brown
– volume: 15
  start-page: 1595
  year: 2013
  ident: 16
  article-title: HOTAIR, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma
  publication-title: Neuro Oncol
  doi: 10.1093/neuonc/not131
  contributor:
    fullname: Kang
– volume: 26
  start-page: 3015
  year: 2008
  ident: 39
  article-title: Stem cell-related “self-renewal” signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2007.15.7164
  contributor:
    fullname: Dietrich
– volume: 32
  start-page: 42
  year: 2017
  ident: 25
  article-title: Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2017.06.003
  contributor:
    fullname: Lin
– volume: 21
  start-page: 1050
  year: 2007
  ident: 50
  article-title: Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
  publication-title: Genes & development
  doi: 10.1101/gad.1524107
  contributor:
    fullname: Yu
– volume: 26
  start-page: 3015
  year: 2008
  ident: 21
  article-title: Stem cell-related “self-renewal” signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma
  publication-title: Journal of clinical oncology
  doi: 10.1200/JCO.2007.15.7164
  contributor:
    fullname: Dietrich
– volume: 59
  start-page: 1169
  year: 2011
  ident: 4
  article-title: The brain tumor microenvironment
  publication-title: Glia
  doi: 10.1002/glia.21136
  contributor:
    fullname: Kettenmann
– volume: 129
  start-page: 1311
  year: 2007
  ident: 10
  article-title: Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs
  publication-title: Cell
  doi: 10.1016/j.cell.2007.05.022
  contributor:
    fullname: Chang
– volume: 1856
  start-page: 151
  year: 2015
  ident: 13
  article-title: LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbcan.2015.07.001
  contributor:
    fullname: Mandal
– volume: 35
  start-page: 722
  year: 2015
  ident: 46
  article-title: Calycosin and genistein induce apoptosis by inactivation of HOTAIR/p-Akt signaling pathway in human breast cancer MCF-7 cells
  publication-title: Cell Physiol Biochem
  doi: 10.1159/000369732
  contributor:
    fullname: Huang
– volume: 21
  start-page: 2933
  year: 2005
  ident: 59
  article-title: MatInspector and beyond: promoter analysis based on transcription factor binding sites
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bti473
  contributor:
    fullname: Werner
– volume: 70
  start-page: 9
  year: 2011
  ident: 2
  article-title: Current concepts and management of glioblastoma
  publication-title: Ann Neurol
  doi: 10.1002/ana.22425
  contributor:
    fullname: Stupp
– volume: 10
  start-page: 38
  year: 2011
  ident: 8
  article-title: The functional role of long non-coding RNA in human carcinomas
  publication-title: Molecular cancer
  doi: 10.1186/1476-4598-10-38
  contributor:
    fullname: Lam
– volume: 19
  start-page: R152
  year: 2010
  ident: 11
  article-title: Large non-coding RNAs: missing links in cancer?
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddq353
  contributor:
    fullname: Rinn
– volume: 4
  start-page: 627
  year: 2013
  ident: 65
  article-title: Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation
  publication-title: Caspian J Intern Med
  contributor:
    fullname: Hajian-Tilaki
– volume: 464
  start-page: 1071
  year: 2010
  ident: 30
  article-title: Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
  publication-title: Nature
  doi: 10.1038/nature08975
  contributor:
    fullname: Kong
– volume: 120
  start-page: 1535
  year: 2010
  ident: 41
  article-title: HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype
  publication-title: J Clin Invest
  doi: 10.1172/JCI39534
  contributor:
    fullname: Weber
– volume: 18
  start-page: 605
  year: 2012
  ident: 52
  article-title: Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
  publication-title: Nature medicine
  doi: 10.1038/nm.2661
  contributor:
    fullname: Woster
– volume: 25
  start-page: 402
  year: 2001
  ident: 62
  article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
  publication-title: Methods
  doi: 10.1006/meth.2001.1262
  contributor:
    fullname: Schmittgen
– volume: 9
  start-page: 157
  year: 2006
  ident: 24
  article-title: Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2006.02.019
  contributor:
    fullname: Feuerstein
– volume: 28
  start-page: 93
  year: 2017
  ident: 45
  article-title: Schisandrin B inhibits the proliferation and invasion of glioma cells by regulating the HOTAIR-micoRNA-125a-mTOR pathway
  publication-title: Neuroreport
  doi: 10.1097/WNR.0000000000000717
  contributor:
    fullname: Liu
– volume: 11
  start-page: 1068
  year: 2004
  ident: 34
  article-title: Intragenic DNA methylation alters chromatin structure and elongation efficiency in mammalian cells
  publication-title: Nature structural & molecular biology
  doi: 10.1038/nsmb840
  contributor:
    fullname: Groudine
– volume: 17
  start-page: 2438
  year: 2007
  ident: 48
  article-title: Synthesis and biological evaluation of pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110alpha inhibitors
  publication-title: Bioorganic & medicinal chemistry letters
  doi: 10.1016/j.bmcl.2007.02.032
  contributor:
    fullname: Parker
– volume: 7
  start-page: 1169
  year: 2011
  ident: 5
  article-title: Recent advancements in multimodality treatment of gliomas
  publication-title: Future Oncol
  doi: 10.2217/fon.11.102
  contributor:
    fullname: Chakravarti
– volume: 6
  start-page: 537
  year: 2015
  ident: 19
  article-title: Long non-coding RNA HOTAIR promotes glioblastoma cell cycle progression in an EZH2 dependent manner
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.2681
  contributor:
    fullname: Yang
– volume: 12
  start-page: 1
  year: 2015
  ident: 14
  article-title: HOTAIR: an oncogenic long non-coding RNA in different cancers
  publication-title: Cancer Biol Med
  doi: 10.7497/j.issn.2095-3941.2015.0006
  contributor:
    fullname: Salavaty
– volume: 6
  start-page: 8353
  year: 2015
  ident: 31
  article-title: HOTAIR is a therapeutic target in glioblastoma
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.3229
  contributor:
    fullname: Yang
– volume: 70
  start-page: 9243
  year: 2010
  ident: 40
  article-title: MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-10-1250
  contributor:
    fullname: Jones
– volume: 3
  start-page: 32
  year: 1950
  ident: 64
  article-title: Index for rating diagnostic tests
  publication-title: Cancer
  doi: 10.1002/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3
  contributor:
    fullname: Youden
– volume: 6
  start-page: 7657
  year: 2015
  ident: 26
  article-title: A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.3150
  contributor:
    fullname: Rocha
– volume: 136
  start-page: 629
  year: 2009
  ident: 7
  article-title: Evolution and functions of long noncoding RNAs
  publication-title: Cell
  doi: 10.1016/j.cell.2009.02.006
  contributor:
    fullname: Reik
– volume: 70
  start-page: 453
  year: 2010
  ident: 38
  article-title: Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-09-2189
  contributor:
    fullname: Costello
– volume: 64
  start-page: 6503
  year: 2004
  ident: 22
  article-title: Gene expression profiling of gliomas strongly predicts survival
  publication-title: Cancer research
  doi: 10.1158/0008-5472.CAN-04-0452
  contributor:
    fullname: Nelson
– volume: 26
  start-page: 43
  year: 2014
  ident: 53
  article-title: Prognostic value of IDH1 mutations identified with PCR-RFLP assay in acute myeloid leukemia patients
  publication-title: J Egypt Natl Canc Inst
  doi: 10.1016/j.jnci.2013.11.001
  contributor:
    fullname: Moneer
– volume: 32
  start-page: 1584
  year: 2013
  ident: 35
  article-title: BRCA1 is a negative modulator of the PRC2 complex
  publication-title: The EMBO journal
  doi: 10.1038/emboj.2013.95
  contributor:
    fullname: Huang
SSID ssj0000547829
Score 2.3953633
Snippet The lncRNA has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of in glioma, the most...
The lncRNA HOTAIR has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of HOTAIR in...
The lncRNA HOTAIR has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of HOTAIR in...
SourceID pubmedcentral
hal
proquest
crossref
pubmed
SourceType Open Access Repository
Aggregation Database
Index Database
StartPage 15740
SubjectTerms Biochemistry, Molecular Biology
Cancer
Genomics
Life Sciences
Molecular biology
Molecular Networks
Research Paper
SummonAdditionalLinks – databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB615cIFgXilPGQQJ6QUr-Mk9gGhCFEtiBap6kp7i2wn3kZKE9hNK_Zf8JOZySZLF3ri6keieGY832ReAG_SNEqNT5LQWocGCgJ8FCntQpEUhU_5RKneXXBymkxn8ss8nu_B2N5qOMDVraYd9ZOaLeujnz_WH1Dg35PAqyQS71qqY9AHTh8JiQh5H-4IGUli-JMB7W9KfUvUh3rwbd66k2oDa4QInDog3VBU-xcUJvkvBv07lPKGbjq-D_cGUMmyDRc8gL2yeQi_kANY3TYLhhZ-6FpSUuzsNGPTb-fZ5zNWrVhHimq8NkxdrxmlOVwj_CyYXePCeaaZaQpaaxpWbVvmdoziupqWijyzS4rwWeIsG4q0rhj93cXxulpQnA1b1FV7aR7B7PjT-cdpOPRfCB3eAl0YqzT1SpRCFN4ishClimQZS8e1ccILF0dJrHGFsk77whmLws69jjWCJvLgPYYD_MLyKTDt8SKjJF40Z6QQ3E6cKZS3ieQ-4VEZwNvxsPPvmzIbOZknRKT8D5HynkgBvEZybNdRgexp9jWnMU7mp1DqehLAq5FaOUoMuUFMU7ZXq1wgLJHIo0IG8GRDve2zRuIHkO7QdedluzNNddFX5aaMXwQ7h_-98xncRTTWJzwK_hwOuuVV-QIRT2df9nz8G8WHBH0
  priority: 102
  providerName: Scholars Portal
Title The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is an independent prognostic marker in patients with malignant glioma
URI https://www.ncbi.nlm.nih.gov/pubmed/29644006
https://search.proquest.com/docview/2024477324
https://uca.hal.science/hal-01917288
https://pubmed.ncbi.nlm.nih.gov/PMC5884661
Volume 9
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwEB11e-KCQBQIH5WLOCFl1-s4iX2MKtotYguqWmlvUezE20jZpOqmlfov-MnMZJNlF25ccrCdz2d73sRvxgCf4ziIMxdFvjEWHRQk-DiktPVFlOcu5lOluuWC-WU0u5HfFuHiAMIhFqYT7VtTjutqNa7L205bebeyk0EnNvk5P6XgSrQrkxGM4iDYcdE3Cb0lWj3dr2CqKBCThvIcdMLqsZDIoCkDsEYiwGmfox1zNLolMeS_TPNvweSOBTp7Ac976siSzSO-hIOifgW_EGdWNfWSoR_v24ZMEbu6TNjsx3VyccXKNWvJHA2TQ1ZVT4yCGR6RZObMPGHDRaJZVufUNqtZud0Yt2Wk3qobSuXMVqTjucda1qdiXTP6h4vlVbkkNQ1bVmWzyo7g5uzr9enM73dZ8C2O9dYPVRw7JQohcmeQP4hCBbIIpeU6s8IJGwZRqLGFMla73GYGhzR3OtRIjWid7jUc4hsWb4Fph9MVheqi0yKF4GZqs1w5E0nuIh4UHnwZPnZ6t0mmkZITQiClf0BKO5A8-IRwbNtRGuxZ8j2lMk5OplDqcerByYBWiuOCFjuyumge1qlA8iGxJwrpwZsNettrDeB7EO_hunez_Rrsil3u7b7rvfvvM9_DM-RcXVij4B_gsL1_KD4ir2nNMYzOF1M8zqU67vr0b5b3_Ng
link.rule.ids 230,315,733,786,790,891,2236,24346,27955,27956,53825,53827
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3JbtswECWS9NBeuqCburJFTwUky9RGHoWggdLabhE4hW-CSImOUJkKYjlA-hX95M5oce301F5FaiFmyHkjvnkk5EMUeVGmw9CWUkGCAgAfppRQNgvzXEfumPN2u2A6C5Nz__MiWByQYKiFaUn7SpaOqVaOKS9abuXlSo0Gntjo2_QYiyshrowOyR2YryzYSdI7SW8f4p7o9zB56LFRjUoHLbXaYT5gaNQAFgAFXDzpaCcgHV4gHfJvrHmbMrkTg04ekO_D13fUkx_OppGO-nlL2PGfh_eQ3O9RKY275kfkoDCPyS9wIVrVZklNbWxVY5SjZ7OYJl_n8ekZLde0wUg3rDtZVd1QrJO4BvyaU3kDHRexoJnJsW9maLk9c7ehSAwzNapE0xVShK6glfYqr2uKv4fhelUukahDl1VZr7In5Pzk0_w4sfsDHGwFy0hjBzyKNGcFY7mWAE1YwT2_CHzlikwxzVTghYGAHlwqoXOVSVgtXC0CAagLtwCfkiMYYfGcUKFhJcQqYMiHfMZcOVZZzrUMfVeHrldY5ONgxfSy0-lIMb9B66d_rJ-21rfIe7Dzth8qbCfxJMVrLuavjPPrsUXeDW6QwpTDfZTMFPVmnTLANT44OfMt8qxzi-2zBq-ySLTnMHsv228BN2hlvXuzv_jvO9-Su8l8Okknp7MvL8k9gHZt9SRzX5Gj5mpTvAb41Mg37WT5DXk9HRg
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3JbtswECWaFCh66YIuUVe26KmAFlMbeRTSGk6buEGQAEYvgkiJjlCZMmI5QPoV_eTOaHHt9JarNJJA8JHzRnx8JORTHPtxpqPIllJBgQIEH4aUUDaL8lzH3ojzdrngZBpNLoJvs3C2ddRXK9pXsnRMtXBMedlqK5cL5Q46Mff05BA3V0JecZe5dvfIfRizLN4q1Dtb7wByn-jXMXnkM7dGt4NWXu2wAHg0-gALoAMenna0lZT2LlES-T_fvC2b3MpD48fk59CCTn7yy1k30lG_b5k73qmJT8ijnp3SpAt5Su4V5hn5A1CiVW3m1NTGVjVmO3o2Tejkx3lydEbLFW0w4w3zT1ZVNxT3S1wDj82pvIHAWSJoZnKMzQwtN2fvNhQFYqZGt2i6QKnQFdylvdvriuJvYrhelXMU7NB5VdaL7Dm5GH89P5zY_UEOtoLppLFDHseas4KxXEugKKzgflCEgfJEpphmKvSjUEAEl0roXGUSZg1Pi1AA-8KlwBdkH1pYHBAqNMyIuBsY6qKAMU-OVJZzLaPA05HnFxb5PPRkuuz8OlKscxAB6T8EpC0CLPIR-noTh07bk-Q4xWse1rGM8-uRRT4MUEhh6OF6SmaKer1KGfCbAMDOAou87KCxedeALIvEO6DZ-djuHYBCa-_dd_2rOz_5njw4_TJOj4-m31-Th8Dw2k2UzHtD9purdfEWWFQj37Xj5S9NtB-Y
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+long+non-coding+RNA+HOTAIR+is+transcriptionally+activated+by+HOXA9+and+is+an+independent+prognostic+marker+in+patients+with+malignant+glioma&rft.jtitle=Oncotarget&rft.au=Xavier-Magalh%C3%A3es%2C+Ana&rft.au=Gon%C3%A7alves%2C+C%C3%A9line+S.&rft.au=Fogli%2C+Anne&rft.au=Louren%C3%A7o%2C+Tatiana&rft.date=2018-03-20&rft.pub=Impact+Journals+LLC&rft.eissn=1949-2553&rft.volume=9&rft.issue=21&rft.spage=15740&rft.epage=15756&rft_id=info:doi/10.18632%2Foncotarget.24597&rft_id=info%3Apmid%2F29644006&rft.externalDBID=PMC5884661
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1949-2553&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1949-2553&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1949-2553&client=summon