Changes in Brain Swelling and Infarction Volume over Four Days After Hypoxia Ischemia in Neonatal Rats

• Published in: Acta neurochirurgica. Supplement Vol. 121; p. 111
• Main Authors: McBride, Devin W, Jacob, Christine, Doycheva, Desislava, Dixon, Brandon J, Malaguit, Jay, Lekic, Tim, Tang, Jiping, Zhang, John H
• Format: Journal Article
• Language: English
• Published: Austria 2016
• Subjects: Animals; Animals, Newborn; Brain - pathology; Brain Edema - pathology; Brain Infarction - pathology; Disease Models, Animal; Disease Progression; Hypoxia-Ischemia, Brain - pathology; Organ Size; Rats; Rats, Sprague-Dawley; Time Factors; Brain swelling; HI; Stroke; Infarct; Hypoxia ischemia

The leading cause of morbidity and mortality in infants is hypoxia-ischemia (HI). The current therapies for HI have limited success, in part due to a lack of understanding of HI pathophysiology and underlying mechanisms. Herein, a neonatal rat model of HI was used to examine the changes in brain swe...