Fermentable Carbohydrates [FODMAPs] Exacerbate Functional Gastrointestinal Symptoms in Patients With Inflammatory Bowel Disease: A Randomised, Double-blind, Placebo-controlled, Cross-over, Re-challenge Trial

• Published in: Journal of Crohn's and colitis Vol. 11; no. 12; pp. 1420 - 1429
• Main Authors: Cox, Selina R, Prince, Alexis C, Myers, Clio E, Irving, Peter M, Lindsay, James O, Lomer, Miranda C, Whelan, Kevin
• Format: Journal Article
• Language: English
• Published: England 04.12.2017
• Subjects: Abdominal Pain - etiology; Adult; Aged; Colitis, Ulcerative - diet therapy; Colitis, Ulcerative - physiopathology; Crohn Disease - diet therapy; Crohn Disease - physiopathology; Cross-Over Studies; Defecation; Diarrhea - etiology; Dietary Carbohydrates - adverse effects; Dietary Carbohydrates - metabolism; Double-Blind Method; Feces - chemistry; Female; Fermentation; Flatulence - etiology; Fructans - adverse effects; Galactose - adverse effects; Humans; Leukocyte L1 Antigen Complex - analysis; Male; Middle Aged; Oligosaccharides - adverse effects; Sorbitol - adverse effects; Symptom Assessment; Young Adult; Inflammatory bowel disease; functional gastrointestinal symptoms; FODMAPs
• ISSN: 1873-9946; 1876-4479
• DOI: 10.1093/ecco-jcc/jjx073

Preliminary evidence suggests that fermentable carbohydrate restriction might ameliorate functional gastrointestinal symptoms [FGS] in inflammatory bowel disease [IBD]. Our aim was to determine whether fermentable carbohydrates exacerbate FGS in IBD using a randomised, double-blinded, placebo-contro...