Methamphetamine modulates the production of interleukin-6 and tumor necrosis factor-alpha via the cAMP/PKA/CREB signaling pathway in lipopolysaccharide-activated microglia

• Published in: International immunopharmacology Vol. 56; pp. 168 - 178
• Main Authors: Wang, Biao, Chen, Teng, Wang, Jing, Jia, Yuwei, Ren, Huixun, Wu, Feng, Hu, Mei, Chen, Yanjiong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2018; Elsevier BV
• Subjects: Animals; cAMP; Cell Line; Colforsin - pharmacology; Cyclic AMP - metabolism; Cyclic AMP response element-binding protein; Cyclic AMP Response Element-Binding Protein - metabolism; Cyclic AMP-Dependent Protein Kinases - metabolism; Cytokines; Extracellular signal-regulated kinase; Forskolin; IL-6; Immune response; Immune system; Immunologic Factors - pharmacology; Inflammation; Interleukin 6; Interleukin-6 - metabolism; Kinases; Lipopolysaccharides; Lipopolysaccharides - immunology; MAP kinase; Methamphetamine; Methamphetamine - pharmacology; Mice; Mice, Inbred C57BL; Microglia; Microglia - drug effects; Microglia - physiology; Microglial cells; Phosphorylation; Protein kinase A; Proteins; Signal Transduction; Signaling; TNF-α; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Tumors; Microglial cells; TNF-α; cAMP; IL-6; Methamphetamine

Methamphetamine (METH) elicits neuroinflammatory effects that may implicate its regulatory role on the microglial immune response. However, the mechanism underlying this remains unclear. In the present study, the effects of METH on lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) and tumor necr...