UCHL1 acts as a prognostic factor and promotes cancer stemness in cervical squamous cell carcinoma
The incidence and death rate of cervical cancer rank fourth among female malignant tumors worldwide. A growing number of researches are devoted to exploring more effective treatment methods and cancer stem cells (CSCs) are thought to be a potential therapeutic target in cervical cancer. In our study...
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Published in | Pathology, research and practice Vol. 247; p. 154574 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier GmbH
01.07.2023
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Abstract | The incidence and death rate of cervical cancer rank fourth among female malignant tumors worldwide. A growing number of researches are devoted to exploring more effective treatment methods and cancer stem cells (CSCs) are thought to be a potential therapeutic target in cervical cancer. In our study, we focused on the expression and function of UCHL1 in cervical squamous cell carcinoma (CESC).
We detected and the expression of UCHL1 in 134 CESC patients through immunohistochemistry and further confirm UCHL1 was a prognostic factor by univariate and multivariate analysis. Then, according to TCGA database for CESC, we found that UCHL1 expression correlated with the markers associated with CSCs (CD133, ABCG2 and SOX2). Therefore, we used western blot and spheroid formation assays to future evaluate the function of UCHL1 on cancer stemness in C-33A and SiHa cell lines. At the same time, we detected the cell proliferation, migration and invasion change by CCK-8 assay, scratch assay and transwell assay, when UCHL1 was knockdown or overexpressed. Finally, xenograft models were used to examine the effect of UCHL1 in vivo.
We found the expression of UCHL1 in mRNA and protein was higher in tumor than in paired normal tissue and was a prognostic factor in CESC. The UCHL1 high expression group showed a shorter survival in the overall survival. According to TCGA database, the expression of UCHL1 was correlated with CD133, ABCG2 and SOX2. The results of sphere-forming ability and CSCs related markers expression were showed UCHL1 promoted cancer stemness in CESC. Similarly, CCK-8 assay, scratch assay and transwell assay were applied to demonstrate that overexpression of UCHL1 promoted the proliferation, migration and invasion in SiHa, but when UCHL1 was knockdown in C-33A, the function of UCHL1 displayed the opposite result. Finally, knockdown UCHL1 inhibited CESC tumor propagation in xenograft models.
Our results suggest that UCHL1 is a prognostic factor and correlated with cancer stemness, proliferation, migration and invasion of CESC, which may provide a novel therapeutic strategy for CESC treatment. |
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AbstractList | The incidence and death rate of cervical cancer rank fourth among female malignant tumors worldwide. A growing number of researches are devoted to exploring more effective treatment methods and cancer stem cells (CSCs) are thought to be a potential therapeutic target in cervical cancer. In our study, we focused on the expression and function of UCHL1 in cervical squamous cell carcinoma (CESC).
We detected and the expression of UCHL1 in 134 CESC patients through immunohistochemistry and further confirm UCHL1 was a prognostic factor by univariate and multivariate analysis. Then, according to TCGA database for CESC, we found that UCHL1 expression correlated with the markers associated with CSCs (CD133, ABCG2 and SOX2). Therefore, we used western blot and spheroid formation assays to future evaluate the function of UCHL1 on cancer stemness in C-33A and SiHa cell lines. At the same time, we detected the cell proliferation, migration and invasion change by CCK-8 assay, scratch assay and transwell assay, when UCHL1 was knockdown or overexpressed. Finally, xenograft models were used to examine the effect of UCHL1 in vivo.
We found the expression of UCHL1 in mRNA and protein was higher in tumor than in paired normal tissue and was a prognostic factor in CESC. The UCHL1 high expression group showed a shorter survival in the overall survival. According to TCGA database, the expression of UCHL1 was correlated with CD133, ABCG2 and SOX2. The results of sphere-forming ability and CSCs related markers expression were showed UCHL1 promoted cancer stemness in CESC. Similarly, CCK-8 assay, scratch assay and transwell assay were applied to demonstrate that overexpression of UCHL1 promoted the proliferation, migration and invasion in SiHa, but when UCHL1 was knockdown in C-33A, the function of UCHL1 displayed the opposite result. Finally, knockdown UCHL1 inhibited CESC tumor propagation in xenograft models.
Our results suggest that UCHL1 is a prognostic factor and correlated with cancer stemness, proliferation, migration and invasion of CESC, which may provide a novel therapeutic strategy for CESC treatment. BACKGROUNDThe incidence and death rate of cervical cancer rank fourth among female malignant tumors worldwide. A growing number of researches are devoted to exploring more effective treatment methods and cancer stem cells (CSCs) are thought to be a potential therapeutic target in cervical cancer. In our study, we focused on the expression and function of UCHL1 in cervical squamous cell carcinoma (CESC). METHODSWe detected and the expression of UCHL1 in 134 CESC patients through immunohistochemistry and further confirm UCHL1 was a prognostic factor by univariate and multivariate analysis. Then, according to TCGA database for CESC, we found that UCHL1 expression correlated with the markers associated with CSCs (CD133, ABCG2 and SOX2). Therefore, we used western blot and spheroid formation assays to future evaluate the function of UCHL1 on cancer stemness in C-33A and SiHa cell lines. At the same time, we detected the cell proliferation, migration and invasion change by CCK-8 assay, scratch assay and transwell assay, when UCHL1 was knockdown or overexpressed. Finally, xenograft models were used to examine the effect of UCHL1 in vivo. RESULTSWe found the expression of UCHL1 in mRNA and protein was higher in tumor than in paired normal tissue and was a prognostic factor in CESC. The UCHL1 high expression group showed a shorter survival in the overall survival. According to TCGA database, the expression of UCHL1 was correlated with CD133, ABCG2 and SOX2. The results of sphere-forming ability and CSCs related markers expression were showed UCHL1 promoted cancer stemness in CESC. Similarly, CCK-8 assay, scratch assay and transwell assay were applied to demonstrate that overexpression of UCHL1 promoted the proliferation, migration and invasion in SiHa, but when UCHL1 was knockdown in C-33A, the function of UCHL1 displayed the opposite result. Finally, knockdown UCHL1 inhibited CESC tumor propagation in xenograft models. CONCLUSIONOur results suggest that UCHL1 is a prognostic factor and correlated with cancer stemness, proliferation, migration and invasion of CESC, which may provide a novel therapeutic strategy for CESC treatment. |
ArticleNumber | 154574 |
Author | Tan, Xiao Jia, Qingge Yang, Yanru Wang, Hongjie Wang, Ke Yin, Zhiyong Xiao, Xin Chai, Jia Liu, Jin Sun, Yameng Li, Mingyang |
Author_xml | – sequence: 1 givenname: Qingge surname: Jia fullname: Jia, Qingge organization: Department of Reproductive Endocrinology, Xi'an International Medical Center Hospital, Northwest University, Xi’an, China – sequence: 2 givenname: Hongjie surname: Wang fullname: Wang, Hongjie organization: Department of Military and Special medicine, No. 971 Hospital of the PLA Navy, Qingdao, China – sequence: 3 givenname: Xin surname: Xiao fullname: Xiao, Xin organization: Department of Military and Special medicine, No. 971 Hospital of the PLA Navy, Qingdao, China – sequence: 4 givenname: Yameng surname: Sun fullname: Sun, Yameng organization: Department of Military and Special medicine, No. 971 Hospital of the PLA Navy, Qingdao, China – sequence: 5 givenname: Xiao surname: Tan fullname: Tan, Xiao organization: Center of Medical Security, No. 971 Hospital of the PLA Navy, Qingdao, China – sequence: 6 givenname: Jia surname: Chai fullname: Chai, Jia organization: State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi’an, China – sequence: 7 givenname: Yanru surname: Yang fullname: Yang, Yanru organization: State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi’an, China – sequence: 8 givenname: Zhiyong surname: Yin fullname: Yin, Zhiyong email: zhiyong_yin@163.com organization: Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an, China – sequence: 9 givenname: Mingyang orcidid: 0000-0003-1766-7867 surname: Li fullname: Li, Mingyang email: limingyang1108@sina.com organization: State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi’an, China – sequence: 10 givenname: Ke surname: Wang fullname: Wang, Ke email: wang.ke@000516.cn organization: Department of Reproductive Medicine, Xi’an Gaoxin Hospital, Xi’an, China – sequence: 11 givenname: Jin surname: Liu fullname: Liu, Jin email: 1041465845@qq.com organization: State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi’an, China |
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Keywords | UCHL1 Prognosis Cancer stem cells CESC Migration |
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Snippet | The incidence and death rate of cervical cancer rank fourth among female malignant tumors worldwide. A growing number of researches are devoted to exploring... BACKGROUNDThe incidence and death rate of cervical cancer rank fourth among female malignant tumors worldwide. A growing number of researches are devoted to... |
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SubjectTerms | Bone Neoplasms Breast Neoplasms Cancer stem cells Carcinoma, Squamous Cell - pathology Cell Line, Tumor Cell Proliferation - genetics CESC Female Humans Migration Prognosis Sincalide - pharmacology Sincalide - therapeutic use Ubiquitin Thiolesterase UCHL1 Uterine Cervical Neoplasms - pathology |
Title | UCHL1 acts as a prognostic factor and promotes cancer stemness in cervical squamous cell carcinoma |
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