3D-aligned tetrameric ion channels with universal residue labels for comparative structural analysis

• Published in: Biophysical journal Vol. 124; no. 2; pp. 458 - 470
• Main Authors: Tikhonov, Denis B., Korkosh, Vyacheslav S., Zhorov, Boris S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.01.2025
• Subjects: Amino Acid Sequence; Ion Channels - chemistry; Ion Channels - metabolism; Models, Molecular; Protein Multimerization

Despite their large functional diversity and poor sequence similarity, tetrameric and pseudotetrameric potassium, sodium, calcium, and cyclic-nucleotide gated channels, as well as two-pore channels, transient receptor potential channels, and ionotropic glutamate receptor channels, share a common fol...