The role of the m6A/m demethylase FTO in memory is both task and sex-dependent in mice

• Published in: Neurobiology of learning and memory Vol. 210; p. 107903
• Main Authors: Leonetti, Amanda M., Galluzzo, Isabella R., McLean, Timothy A.D., Stefanelli, Gilda, Ramnaraign, Fiona, Holm, Samuel, Winston, Stephen M., Reeves, Isaiah L., Brimble, Mark A., Walters, Brandon J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2024
• Subjects: Epigenetics; Epitranscriptomics; Fto; Learning and Memory; m6A; RNA methylation; Fto; Epigenetics; m6A; Epitranscriptomics; Learning and Memory; RNA methylation

•Depleting FTO impaired object location match memory in male mice.•Depleting FTO had no effect on novel object memory in male mice.•Depleting FTO has no role in female novel object or object location memory.•Depletion of FTO has a anxiolytic effect on male mice only in the elevated plus maze. Format...