Phosphorylation Code of Human Nucleophosmin Includes Four Cryptic Sites for Hierarchical Binding of 14-3-3 Proteins
[Display omitted] •NPM1 is phosphorylated by PKA at multiple sites phosphorylatable in vivo.•Phosphorylation drives NPM1 unfolding, monomerization and recruits 14-3-3.•Four NPM1 phosphoserines are recognized by all seven human 14-3-3 isoforms.•Binding of phosphomotifs is hierarchical, pS293 > pS4...
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Published in | Journal of molecular biology Vol. 436; no. 12; p. 168592 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Ltd
15.06.2024
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Subjects | |
Online Access | Get full text |
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