Unprecedented 4,9‐Seco‐Oplopanane and Seven Drimane Sesquiterpenoids from the Chinese Liverwort Lejeunea flava (Sw.) Nees

An unprecedented 4,9‐seco‐oplopanane (1), two undescribed drimane epimers (2 and 3), and five known drimane sesquiterpenoids (4–8) were isolated from the Chinese liverwort Lejeunea flava (Sw.) Nees. The structures of the new sesquiterpenoids were determined using nuclear magnetic resonance spectrosc...

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Published inChemistry & biodiversity Vol. 19; no. 9; pp. e202200559 - n/a
Main Authors Zhu, Ming‐Zhu, Li, Yi, Zhou, Jin‐Chuan, Wang, Tian, Qian, Li‐Lin, Zhang, Jiao‐Zhen, Han, Jing‐Jing, Xu, Ze‐Jun, Shen, Tao, Lou, Hong‐Xiang
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 01.09.2022
Subjects
anti-inflammatory activity
Aquatic plants
Circular dichroism
Cytotoxicity
Dichroism
Lejeunea flava
Lipopolysaccharides
liverworts
Macrophages
Magnetic resonance spectroscopy
Nitric oxide
NMR
NMR spectroscopy
Nuclear magnetic resonance
Sesquiterpenoids
Toxicity
Tumor cell lines
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Summary:An unprecedented 4,9‐seco‐oplopanane (1), two undescribed drimane epimers (2 and 3), and five known drimane sesquiterpenoids (4–8) were isolated from the Chinese liverwort Lejeunea flava (Sw.) Nees. The structures of the new sesquiterpenoids were determined using nuclear magnetic resonance spectroscopy, electronic circular dichroism calculations, and single‐crystal X‐ray diffraction measurements. The inhibitory capacity of the new compounds against nitric oxide production in lipopolysaccharide‐induced RAW 264.7 murine macrophages, along with the cytotoxicity of the new compounds against A549 and HepG‐2 human cancer cell lines, were discussed.
Bibliography:ObjectType-Article-1
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ISSN:1612-1872
1612-1880
1612-1880
DOI:10.1002/cbdv.202200559