Use of Placebo in Urologic Oncology Randomized Controlled Trials

• Published in: Urology practice Vol. 11; no. 6; pp. 940 - 948
• Main Authors: Cheng, Zijing, Campbell, Timothy, Hunt, Trevor C., Li, Ashley, Doersch, Karen, Bandari, Jathin
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Wolters Kluwer 01.11.2024
• Subjects: Humans; Medical Oncology - ethics; Medical Oncology - methods; Placebo Effect; Placebos - administration & dosage; Placebos - adverse effects; Placebos - therapeutic use; Randomized Controlled Trials as Topic - ethics; Randomized Controlled Trials as Topic - methods; Urologic Neoplasms - drug therapy; placebos; clinical trials; neoplasms; randomized controlled trials; urology

Introduction:Use of placebo in oncology randomized controlled trials (RCT) is ethically controversial. Placebo may introduce bias, as toxicity profiles of treatment arms can inadvertently unblind subjects and investigators. We investigated the use of placebo in urologic oncology RCTs, hypothesizing...