Tight junction regulation, intestinal permeability, and mucosal immunity in gastrointestinal health and disease

• Published in: Current opinion in gastroenterology Vol. 41; no. 1; p. 46
• Main Authors: Saha, Kushal, Zhou, Yin, Turner, Jerrold R
• Format: Journal Article
• Language: English
• Published: United States 01.01.2025
• Subjects: Animals; Gastrointestinal Diseases - immunology; Gastrointestinal Diseases - physiopathology; Humans; Immunity, Mucosal; Inflammatory Bowel Diseases - immunology; Inflammatory Bowel Diseases - metabolism; Inflammatory Bowel Diseases - physiopathology; Intestinal Barrier Function; Intestinal Mucosa - immunology; Intestinal Mucosa - metabolism; Permeability; Tight Junctions - immunology; Tight Junctions - metabolism; Tight Junctions - physiology
• ISSN: 1531-7056
• DOI: 10.1097/MOG.0000000000001066

The contributions of intestinal barrier loss, that is, increased permeability, to multiple disorders, including inflammatory bowel disease (IBD), have been a topic of speculation for many years, and the literature is replete with conclusions based on correlation and speculation. The goal of this art...