A novel synthesis of N-(piperidin-4-yl)-1,3-dihydroindol-2-one via an intramolecular Pd-catalyzed amination

[Display omitted] A novel efficient synthetic route to the pharmaceutical key intermediate N-(piperidin-4-yl)-1,3-dihydroindol-2-one is described. The key step involves a high-yielding intramolecular palladium-catalyzed amination reaction using Buchwald’s X-Phos ligand under mild reaction conditions...

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Bibliographic Details
Published inTetrahedron letters Vol. 45; no. 46; pp. 8535 - 8537
Main Authors van den Hoogenband, Adri, den Hartog, Jack A.J., Lange, Jos H.M., Terpstra, Jan Willem
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 08.11.2004
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
LIGANDS
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Summary:[Display omitted] A novel efficient synthetic route to the pharmaceutical key intermediate N-(piperidin-4-yl)-1,3-dihydroindol-2-one is described. The key step involves a high-yielding intramolecular palladium-catalyzed amination reaction using Buchwald’s X-Phos ligand under mild reaction conditions.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.09.121