Tuberous sclerosis and guttate leukodermas

• Published in: Seminars in cutaneous medicine and surgery Vol. 16; no. 1; p. 30
• Main Author: Jimbow, K
• Format: Journal Article
• Language: English
• Published: United States 01.03.1997
• Subjects: Amyloidosis - diagnosis; Cell Division - genetics; Chromosomes, Human, Pair 16 - genetics; Chromosomes, Human, Pair 9 - genetics; Dendrites - pathology; Diagnosis, Differential; Dopamine beta-Hydroxylase - genetics; Epidermis - pathology; Genes, Tumor Suppressor - genetics; Hair Diseases - pathology; Hair Follicle - pathology; Humans; Hypopigmentation - genetics; Hypopigmentation - pathology; Keratinocytes - pathology; Keratosis - diagnosis; Melanins; Melanocytes - pathology; Melanosis - diagnosis; Microscopy, Electron; Neurotransmitter Agents - genetics; Repressor Proteins - genetics; Repressor Proteins - physiology; Tuberous Sclerosis - genetics; Tuberous Sclerosis - pathology; Tumor Suppressor Proteins

The clinical, histopathologic, and electron microscopic features of guttate leukodermas are reviewed, including the hypomelanoses of the skin and hair observed in the tuberous sclerosis complex (TSC). The hypopigmentation seen in patients with TSC is related primarily to a decrease in the function o...