Axillary sampling and radiotherapy does not compromise the patient with early breast cancer: Trafford database experience

• Published in: European journal of surgical oncology Vol. 21; no. 4; pp. 364 - 367
• Main Authors: Kingston, R.D., Bridger, J., Smith, C.J., Jeacock, J., Robinson, C.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.1995
• Subjects: Adult; Aged; Aged, 80 and over; Axilla; breast cancer; Breast Neoplasms - radiotherapy; Breast Neoplasms - surgery; Disease-Free Survival; Female; Follow-Up Studies; Humans; local recurrence; Lymph Node Excision - methods; Lymphatic Metastasis; Mastectomy, Segmental; Middle Aged; Neoplasm Recurrence, Local; outcome; Radiotherapy, Adjuvant; Registries; survival; Survival Analysis; Treatment Outcome; breast cancer; local recurrence; outcome; survival
• DOI: 10.1016/S0748-7983(95)92351-9
• ISSN: 0748-7983

Local recurrence has been studied in a selected group of 379 patients, 39% of whom underwent simple mastectomy and 61% lumpectomy. The axilla was sampled in 52%, cleared in 8% and untreated in 40%. Axillary recurrence occurred in 16% of patients with a median follow-up of 54 months. Ninety-one per cent of these patients with lymph node recurrence had no surgery or sampling to the axilla, and a third received radiotherapy. Local recurrence was satisfactorily controlled by various modalities of treatment in all but 29 patients. Death related to distant metastasis in all but six of these 29 patients. Analysis suggests that patients with locally uncontrolled disease had aggressive tumours at diagnosis which were larger than average, most often grade 3 histologically and more frequently required mastectomy. Our results support previous studies indicating that survival would not be influenced by more radical surgery but that sampling followed by radiotherapy would have prevented the majority of our lymph node recurrences.