The role of lncRNA binding to RNA‑binding proteins to regulate mRNA stability in cancer progression and drug resistance mechanisms (Review)

• Published in: Oncology reports Vol. 52; no. 5; p. 1
• Main Authors: Zhang, Nianjie, Wen, Kunming
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.11.2024; Spandidos Publications UK Ltd
• Subjects: B cells; Binding proteins; Breast cancer; Cancer; Cancer therapies; Cell death; Cell growth; Cell Proliferation; Development and progression; Disease Progression; Drug resistance; Drug Resistance, Neoplasm - genetics; Drug therapy; Ferroptosis; Gene expression; Gene Expression Regulation, Neoplastic; Glioma; Health aspects; Humans; Kidney cancer; Kinases; Liver cancer; Messenger RNA; Metastasis; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Physiology; Protein binding; Protein synthesis; Proteins; Ribonucleic acid; RNA; RNA Stability; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Signal transduction; Tumors; cancer; long non‑coding RNA; regulation; RNA‑binding protein; mRNA stability
• ISSN: 1021-335X; 1791-2431; 1791-2431
• DOI: 10.3892/or.2024.8801

Cancer is a disease that poses a serious threat to human health, the occurrence and development of which involves complex molecular mechanisms. Long non‑coding RNAs (lncRNAs) and RNA‑binding proteins (RBPs) are important regulatory molecules within cells, which have garnered extensive attention in cancer research in recent years. The binding of lncRNAs and RBPs plays a crucial role in the post‑transcriptional regulation of mRNA, affecting the synthesis of proteins related to cancer by regulating the stability of mRNA. This, in turn, regulates the malignant biological behaviors of tumor cells, such as proliferation and metastasis, and serves an important role in therapeutic resistance. The present study reviewed the role of lncRNA‑RBP interactions in the regulation of mRNA stability in various malignant tumors, with a focus on the molecular mechanisms underlying this regulatory interaction. The aim of the present review was to gain a deeper understanding of these molecular mechanisms to provide new strategies and insights for the precise treatment of cancer.