Synthesis of thymidine dimers containing piperazine in the internucleoside linkage and their incorporation into oligodeoxynucleotides

• Published in: Tetrahedron Vol. 51; no. 7; pp. 2145 - 2154
• Main Authors: Petersen, Gorm Vang, Wengel, Jesper
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 13.02.1995; Elsevier
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; LINKED DINUCLEOSIDES; SOLID-PHASE SYNTHESIS; ANALOGS; BUILDING-BLOCKS; 3'-AMINO-3'-DEOXYTHYMIDINE; OLIGODEOXYRIBONUCLEOTIDES; ANTISENSE OLIGONUCLEOTIDES; DERIVATIVES; HYBRIDIZATION PROPERTIES; FORMACETAL

The synthesis of thymidine dimers in which the natural phosphodiester linkage has been replaced by piperazine (3′-(N(CH 2CH 2) 2N)-5′, 9 and 3′-(N(CH 2CH 2) 2N)-CO-4′, 10) are described. These new dimers were incorporated into oligodeoxynucleotides on an automated DNA-synthesizer using the phosphora...