Inosine and its methyl derivatives: Occurrence, biogenesis, and function in RNA

• Published in: Progress in biophysics and molecular biology Vol. 169-170; pp. 21 - 52
• Main Authors: Dutta, Nivedita, Deb, Indrajit, Sarzynska, Joanna, Lahiri, Ansuman
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2022
• Subjects: A-to-I editing; ADARs; Adenosine - genetics; Adenosine - metabolism; Epitranscriptomic modification; Inosine - genetics; Inosine - metabolism; Methyl derivatives; RNA - metabolism; RNA Editing; Viral defense; Wobble modification; Epitranscriptomic modification; A-to-I editing; Wobble modification; ADARs; Viral defense; Methyl derivatives
• ISSN: 0079-6107; 1873-1732; 1873-1732
• DOI: 10.1016/j.pbiomolbio.2022.01.001

Inosine is one of the most common post-transcriptional modifications. Since its discovery, it has been noted for its ability to contribute to non-Watson-Crick interactions within RNA. Rapidly accumulating evidence points to the widespread generation of inosine through hydrolytic deamination of adeno...