Identifying biomarkers of heterogeneity and transplantation efficacy in retinal pigment epithelial cells

• Published in: The Journal of experimental medicine Vol. 220; no. 12
• Main Authors: Farjood, Farhad, Manos, Justine D, Wang, Yue, Williams, Anne L, Zhao, Cuiping, Borden, Susan, Alam, Nazia, Prusky, Glen, Temple, Sally, Stern, Jeffrey H, Boles, Nathan C
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 04.12.2023
• Subjects: Animals; Biomarkers; Epithelial Cells; Gene Expression Profiling; Neurons; Neuroscience; Rats; Retinal Pigments; Stem Cells & Regeneration

Transplantation of retinal pigment epithelial (RPE) cells holds great promise for patients with retinal degenerative diseases, such as age-related macular degeneration. In-depth characterization of RPE cell product identity and critical quality attributes are needed to enhance efficacy and safety of...