The synthesis and bone resorbing activity of (25R)- and (25S)-26-hydroxycholecalciferol (26-OH-D 3)

• Published in: Journal of steroid biochemistry Vol. 9; no. 12; pp. 1179 - 1182
• Main Authors: Redel, J., Rebut-Bonneton, C., Delbarre, F.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.01.1978

The synthesis of C-25 epimers of 26-hydroxycholecalciferol (26-OH-D 3) (III)—the so far unknown 25-deoxy analogue of the metabolite 25,26(OH) 2D 3—is described. (25R)- or (25S)-26-hydroxycholesterol 3,26-diacetate (I) was converted into the corresponding mixture of 5,7- and 4,6-diene, saponified and...