Bile acid synthesis precursors in familial combined hyperlipidemia: The oxysterols 24S-hydroxycholesterol and 27-hydroxycholesterol

• Published in: Biochemical and biophysical research communications Vol. 446; no. 3; pp. 731 - 735
• Main Authors: Baila-Rueda, Lucía, Mateo-Gallego, Rocío, Jarauta, Estibaliz, de Castro-Orós, Isabel, Bea, Ana M., Cenarro, Ana, Civeira, Fernando
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.04.2014
• Subjects: Adolescent; Adult; Aged; atherosclerosis; bile acids; Bile Acids and Salts - biosynthesis; Body Mass Index; Carotid Intima-Media Thickness; Case-Control Studies; Cholesterol; Desmosterol - blood; Familial combined hypercholesterolemia; Female; genetic disorders; high performance liquid chromatography; Humans; Hydroxycholesterols - blood; hyperlipidemia; Hyperlipidemia, Familial Combined - blood; Hyperlipidemia, Familial Combined - diagnostic imaging; lanosterol; Lanosterol - blood; Male; Middle Aged; Non-cholesterol sterol; Oxysterol; patients; tandem mass spectrometry; Young Adult; Familial combined hypercholesterolemia; Non-cholesterol sterol; Cholesterol; Oxysterol

•Study of the bile acid synthesis by means of oxysterol concentrations in serum in FCHL subjects.•FCHL subjects with oxysterol overproduction had less carotid intima media thickness.•High levels of oxysterols in FCHL and its possible role in atherosclerosis. Familial combined hyperlipidemia (FCHL),...