A novel therapeutic multiepitope vaccine based on oncoprotein E6 and E7 of HPV 16 and 18: An in silico approach

• Published in: BioImpacts : BI Vol. 14; no. 5; pp. 27846 - 13
• Main Authors: Pratiwi, Sari Eka, Ysrafil, Ysrafil, Mardhia, Mardhia, Mahyarudin, Mahyarudin, Ilmiawan, Muhammad Inam, Trianto, Heru Fajar, Liana, Delima Fajar, Amia, Yuri
• Format: Journal Article
• Language: English
• Published: Iran Tabriz University of Medical Sciences 01.01.2024; Tabriz University of Medical Sciences (TUOMS Publishing Group)
• Subjects: Adenomatous polyposis coli; Antigen-presenting cells; Antigenicity; Antigens; Apoptosis; BAK protein; Bcl-2 protein; Bioinformatics; Biotechnology; Cancer immunotherapy; Cancer vaccines; Carcinogenesis; Cell cycle; Cell proliferation; Cervical cancer; Cytotoxicity; Epitope mapping; FasL protein; Genomes; Human papillomavirus; Immunogenicity; Immunological tolerance; Infections; Lymphocytes; Lymphocytes T; Mutation; Neoantigens; Oncoproteins; Original; Peptides; Protein transport; Proteins; Therapeutic targets; Toxicity; Tumor necrosis factor-TNF; Tumors; Vaccine development; Vaccines; Viral infections; Womens health; Indonesia; Multiepitope vaccine; HPV vaccine; Therapeutic vaccine; Reverse vaccinology; Immunoinformatic

The current vaccine strategies to prevent cervical cancer are effective only for individuals unexposed to HPV, lacking therapeutic effects against pre-existing infections. Multiepitope vaccines, using an immunoinformatic approach, are promising against tumors and viral infections because of their hi...