Extracellular matrix incorporation of normal and NEM-alkylated fibronectin: liver and spleen deposition

• Published in: The American journal of physiology Vol. 269; no. 6 Pt 1; p. G902
• Main Authors: Rebres, R A, McKeown-Longo, P J, Vincent, P A, Cho, E, Saba, T M
• Format: Journal Article
• Language: English
• Published: United States 01.12.1995
• Subjects: Alkylation; Animals; Cells, Cultured; Ethylmaleimide - metabolism; Extracellular Matrix - metabolism; Fibroblasts - metabolism; Fibronectins - metabolism; Humans; Kupffer Cells - metabolism; Liver - cytology; Liver - metabolism; Rats; Reference Values; Spleen - metabolism; Time Factors; Tissue Distribution

The incorporation of plasma fibronectin (pFn) into the extracellular matrix (ECM) is believed to influence tissue integrity, wound repair, and vascular permeability. In vitro, matrix assembly of Fn requires the binding of soluble Fn to cell-associated matrix assembly sites. Alkylation of human pFn (...