Developmentally regulated GTP-binding protein 2 ameliorates EAE by suppressing the development of TH17 cells

• Published in: Clinical immunology (Orlando, Fla.) Vol. 150; no. 2; pp. 225 - 235
• Main Authors: Ko, Myoung Seok, Kim, Hyo Jeong, Kim, Hong Kyung, Yoon, Nal Ae, Lee, Unn Hwa, Lee, Sang Chul, Chung, Dae Kyun, Lee, Byung Ju, Suh, Jae Hee, Cho, Wha Ja, Park, Jeong Woo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2014
• Subjects: Animals; Antigen-Presenting Cells - immunology; Antigen-Presenting Cells - metabolism; Cell Differentiation; Co-Repressor Proteins - metabolism; Cytokines - metabolism; DRG2; EAE; Encephalomyelitis, Autoimmune, Experimental - genetics; Encephalomyelitis, Autoimmune, Experimental - immunology; Encephalomyelitis, Autoimmune, Experimental - metabolism; Gene Expression; Genotype; GTP-Binding Proteins - genetics; GTP-Binding Proteins - metabolism; IL-6; Inflammation Mediators - metabolism; Interleukin-6 - genetics; Interleukin-6 - metabolism; Male; Mice; Mice, Transgenic; NF-kappa B - metabolism; NF-κB; PPAR gamma - metabolism; PPARγ; Promoter Regions, Genetic; Protein Binding; T-Lymphocyte Subsets - cytology; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism; TH17; Th17 Cells - cytology; Th17 Cells - immunology; Th17 Cells - metabolism; EAE; NF-κB; DRG2; TH17; PPARγ; IL-6; T(H)17

Developmentally regulated GTP-binding protein 2 (DRG2) represents a novel subclass of GTP-binding proteins. We here report that transgenic overexpression of DRG2 in mice ameliorates experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). The protective effect of D...