A challenging synthetic approach to phosphonium ylide-betaines of the pyrimidine series

• Published in: Tetrahedron Vol. 52; no. 26; pp. 8835 - 8852
• Main Authors: Meervelt, Luc Van, Smolii, Oleg B., Mishchenko, Nikolai I., Shakhnin, Dmitrii B., Romanenko, Evgenii A., Drach, Boris S.
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 1996; Elsevier
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; (2,2-DICHLORO-1-ACYLAMINOVINYL)TRIPHENYLPHOSPHONIUM CHLORIDES; SALTS; DERIVATIVES

Adducts of the available ylide Ph 3 P + -C̄HCN with acylisocyanates and their thio analogues undergo facile cyclization, promoted by hydrogen chloride in methanol, to give high yields of 2-alkyl(aryl)-4-hydroxy(mercapto)-6-oxo-1,6-dihydropyrimidin-5-yl-triphenyl-phosphonium chlorides suitable to pre...