Inducible nitric oxide synthase expression in chronic viral hepatitis. Evidence for a virus-induced gene upregulation

• Published in: The Journal of clinical investigation Vol. 101; no. 7; pp. 1343 - 1352
• Main Authors: Majano, P L, García-Monzón, C, López-Cabrera, M, Lara-Pezzi, E, Fernández-Ruiz, E, García-Iglesias, C, Borque, M J, Moreno-Otero, R
• Format: Journal Article
• Language: English
• Published: United States 01.04.1998
• Subjects: Cells, Cultured; Chronic Disease; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Viral; Genes, Viral; Hepatitis B - enzymology; Hepatitis B - genetics; Hepatitis B virus; Hepatitis C - enzymology; Hepatitis C - genetics; Humans; Immunohistochemistry; In Situ Hybridization; Nitric Oxide - metabolism; Nitric Oxide Synthase - metabolism; Nitric Oxide Synthase Type II; RNA, Messenger - genetics; Trans-Activators - physiology; Transfection

Increased nitric oxide (NO) production may contribute to the pathological changes featuring in some inflammatory diseases, but the role of NO in chronic viral hepatitis is still unknown. We compared the inducible NO synthase (NOS2) expression in the liver of patients with chronic viral hepatitis wit...