Characterization of Suicidal Erythrocyte Death (Eryptosis) in Dogs

• Published in: Cellular physiology and biochemistry Vol. 54; no. 4; pp. 605 - 614
• Main Authors: Katahira, Ichiro, Neo, Sakurako, Nagane, Masaki, Miyagi, Saki, Hisasue, Masaharu, Bhuyan, Abdulla Al Mamum
• Format: Journal Article
• Language: English
• Published: Germany Cell Physiol Biochem Press GmbH & Co KG 17.06.2020
• Subjects: Animals; Annexin A5 - metabolism; Benzophenanthridines - pharmacology; Calcium - metabolism; Casein Kinase I - antagonists & inhibitors; Caspase Inhibitors; Caspases - metabolism; Cell Size - drug effects; Dogs; Eryptosis; Erythrocytes - drug effects; Erythrocytes - metabolism; Glucose - metabolism; Ionomycin - pharmacology; Janus Kinase 3 - antagonists & inhibitors; Osmotic Pressure - drug effects; Oxidative Stress - drug effects; p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors; Phosphatidylserines - metabolism; Protein Kinase C - antagonists & inhibitors; Protein Kinase Inhibitors - pharmacology; Reactive Oxygen Species - metabolism; Sucrose - pharmacology; tert-Butylhydroperoxide - pharmacology; Eryptosis; Dogs; Annexin; Cell volume; Calcium

Suicidal erythrocyte death (eryptosis) is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface following a Ca entry in the cell. Eryptosis is stimulated by increased cytosolic Ca ([Ca ]i), oxidative stress, energy depletion, or...