CaMKII Modulates the Cardiac Transient Outward K + Current through its Association with Kv4 Channels in Non-Caveolar Membrane Rafts

• Published in: Cellular physiology and biochemistry Vol. 54; no. 1; pp. 27 - 39
• Main Authors: Alday, Aintzane, Ahyayauch, Hasna, Fernández-López, Victor, Echeazarra, Leyre, Urrutia, Janire, Casis, Oscar, Gallego, Mónica
• Format: Journal Article
• Language: English
• Published: Germany Cell Physiol Biochem Press GmbH & Co KG 15.01.2020
• Subjects: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - analysis; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism; Caveolae - metabolism; Cells, Cultured; Humans; Ion Transport; Membrane Microdomains - metabolism; Myocytes, Cardiac - metabolism; Potassium - metabolism; Protein Interaction Maps; Rats, Sprague-Dawley; Shal Potassium Channels - analysis; Shal Potassium Channels - metabolism; Calmodulin; Ito; Kv4.3; Kv4.2; Lipid rafts; Caveola

To test whether the physiological regulation of the cardiac Kv4 channels by the Ca /calmodulin-dependent protein kinase II (CaMKII) is restricted to lipid rafts and whether the interactions observed in rat cardiomyocytes also occur in the human ventricle. Ventricular myocytes were freshly isolated f...