The effect of in utero insulin exposure on tissue iron status in fetal rats

• Published in: Pediatric research Vol. 31; no. 1; pp. 64 - 67
• Main Authors: GEORGIEFF, M. K, KASSNER, R. J, RADMER, W. J, BERARD, D. J, DOSHI, S. R, STONESTREET, B. S
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 1992
• Subjects: Animals; Biological and medical sciences; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Fetus - drug effects; Fetus - metabolism; Hyperinsulinism - metabolism; Insulin - pharmacology; Iron - deficiency; Iron - metabolism; Maternal-Fetal Exchange; Medical sciences; Pregnancy; Pregnancy in Diabetics - metabolism; Rats; Rats, Inbred Strains; Tissue Distribution; Endocrinopathy; Hyperinsulinemia; Animal model; Rat; Diabetes mellitus; Rodentia; Iron; Inorganic element; Insulin; Dose activity relation; Vertebrata; Mammalia; Animal; Fetus; Biological effect

Newborn infants of diabetic mothers have serum biochemical signs of iron deficiency in cord blood directly related to elevations of cord erythropoietin and Hb concentrations. In sheep, chronic fetal hyperinsulinemia results in fetal hypoxemia, expansion of the red cell mass, and decreased iron conce...