Advanced glycosylation end products up-regulate connective tissue growth factor (insulin-like growth factor-binding protein-related protein 2) in human fibroblasts: a potential mechanism for expansion of extracellular matrix in diabetes mellitus

• Published in: Endocrinology (Philadelphia) Vol. 142; no. 5; pp. 1760 - 1769
• Main Authors: Twigg, S M, Chen, M M, Joly, A H, Chakrapani, S D, Tsubaki, J, Kim, H S, Oh, Y, Rosenfeld, R G
• Format: Journal Article
• Language: English
• Published: United States 01.05.2001
• Subjects: Cells, Cultured; Connective Tissue Growth Factor; Diabetes Mellitus - metabolism; Extracellular Matrix - metabolism; Fibroblasts - metabolism; Glycation End Products, Advanced - pharmacology; Growth Substances - biosynthesis; Growth Substances - genetics; Humans; Immediate-Early Proteins - biosynthesis; Immediate-Early Proteins - genetics; Intercellular Signaling Peptides and Proteins; Receptor for Advanced Glycation End Products; Receptors, Immunologic - physiology; RNA, Messenger - analysis; Transforming Growth Factor beta - physiology; Up-Regulation

Expansion of extracellular matrix with fibrosis occurs in many tissues as part of the end-organ complications in diabetes, and advanced glycosylation end products (AGE) are implicated as one causative factor in diabetic tissue fibrosis. Connective tissue growth factor (CTGF), also known as insulin-l...