Brachytherapy at the nanoscale with protein functionalized and intrinsically radiolabeled [169Yb]Yb2O3 nanoseeds

• Published in: European journal of nuclear medicine and molecular imaging Vol. 51; no. 6; pp. 1558 - 1573
• Main Authors: Ghosh, Sanchita, Patra, Sourav, Younis, Muhsin H., Chakraborty, Avik, Guleria, Apurav, Gupta, Santosh K., Singh, Khajan, Rakhshit, Sutapa, Chakraborty, Sudipta, Cai, Weibo, Chakravarty, Rubel
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2024; Springer Nature B.V
• Subjects: Autoradiography; Brachytherapy; Cancer therapies; Cardiology; Computed tomography; Glycoproteins; Imaging; In vivo methods and tests; Medical imaging; Medicine; Medicine & Public Health; Nanoparticles; Neutron irradiation; Neutron radiation; Nuclear Medicine; Nuclear reactors; Oncology; Original Article; Orthopedics; Radiation therapy; Radiochemical analysis; Radiology; Single photon emission computed tomography; Tumors; Radiolabeled nanoparticles; Nanoscale brachytherapy; Theranostics; Intratumoral injection; SPECT; Tumor regression; Cancer

Purpose Classical brachytherapy of solid malignant tumors is an invasive procedure which often results in an uneven dose distribution, while requiring surgical removal of sealed radioactive seed sources after a certain period of time. To circumvent these issues, we report the synthesis of intrinsica...