Polymeric Immunoglobulin Receptor Down-regulation in Chronic Obstructive Pulmonary Disease. Persistence in the Cultured Epithelium and Role of Transforming Growth Factor-β

• Published in: American journal of respiratory and critical care medicine Vol. 190; no. 5; pp. 509 - 521
• Main Authors: Gohy, Sophie T., Detry, Bruno R., Lecocq, Marylène, Bouzin, Caroline, Weynand, Birgit A., Amatngalim, Gimano D., Sibille, Yves M., Pilette, Charles
• Format: Journal Article
• Language: English
• Published: United States 01.09.2014
• Subjects: Aged; Biomarkers - metabolism; Bronchi - metabolism; Case-Control Studies; Down-Regulation; Female; Humans; Immunohistochemistry; Male; Middle Aged; Prospective Studies; Pulmonary Disease, Chronic Obstructive - metabolism; Real-Time Polymerase Chain Reaction; Receptors, Polymeric Immunoglobulin - metabolism; Respiratory Mucosa - metabolism; Severity of Illness Index; Smoking - metabolism; Tissue Culture Techniques; Transforming Growth Factor beta1 - metabolism; Up-Regulation; immunology; IgA; chronic obstructive pulmonary disease

The generation of protective secretory IgA relies on the epithelial polymeric immunoglobulin receptor (pIgR). pIgR expression is reduced in chronic obstructive pulmonary disease (COPD), but correlation to disease severity and underlying mechanisms remains unknown. To address the hypothesis that pIgR...