On-demand drug release from tailored blended electrospun nanofibers
Aiming at the simplification of protocols as well as the improvement of currently available thermo-responsive nanocarrier formulations, we propose an innovative heat-triggered membrane made of electrospun nanofibers to control the release of active molecules at physiological temperature. In order to...
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Published in | Journal of drug delivery science and technology Vol. 52; pp. 8 - 14 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier B.V
01.08.2019
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Subjects | |
Online Access | Get full text |
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Abstract | Aiming at the simplification of protocols as well as the improvement of currently available thermo-responsive nanocarrier formulations, we propose an innovative heat-triggered membrane made of electrospun nanofibers to control the release of active molecules at physiological temperature. In order to control the drug release, the glass transition temperature (Tg) of Eudragit® RS100 was varied by blending different ratios of the polymer with poly(methyl methacrylate), leading to a decrease from 80% to 12% of the total amount of Rhodamine B released within 24 h at 37 °C when a Eudragit® RS100/poly(methyl methacrylate) nanofibers with ratio of 7:3 was considered. Furthermore, the on-demand drug release profiles confirm the absence of premature release at temperatures below the Tg due to restricted mobility of the macromolecular chains. On the contrary, chains mobility was enhanced at temperature above the Tg, promoting a controlled release of drug over time. Eventually, the high viability and proliferation rate of fibroblasts seeded on nanofibers shown by Presto Blue® metabolic assay and confocal images suggested membrane cytocompatibility.
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•Simple method to prepare new class of cytocompatible electrospun nanofibers for on-demand drug delivery is presented.•ON(45 °C)/OFF(37 °C) trigger mechanism well manipulated via glass transition temperature (Tg) as thermo-responsive switch.•The developed nanofibrous membranes may be a potential candidate as targeted and responsive drug-delivery carrier. |
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AbstractList | Aiming at the simplification of protocols as well as the improvement of currently available thermo-responsive nanocarrier formulations, we propose an innovative heat-triggered membrane made of electrospun nanofibers to control the release of active molecules at physiological temperature. In order to control the drug release, the glass transition temperature (Tg) of Eudragit® RS100 was varied by blending different ratios of the polymer with poly(methyl methacrylate), leading to a decrease from 80% to 12% of the total amount of Rhodamine B released within 24 h at 37 °C when a Eudragit® RS100/poly(methyl methacrylate) nanofibers with ratio of 7:3 was considered. Furthermore, the on-demand drug release profiles confirm the absence of premature release at temperatures below the Tg due to restricted mobility of the macromolecular chains. On the contrary, chains mobility was enhanced at temperature above the Tg, promoting a controlled release of drug over time. Eventually, the high viability and proliferation rate of fibroblasts seeded on nanofibers shown by Presto Blue® metabolic assay and confocal images suggested membrane cytocompatibility.
[Display omitted]
•Simple method to prepare new class of cytocompatible electrospun nanofibers for on-demand drug delivery is presented.•ON(45 °C)/OFF(37 °C) trigger mechanism well manipulated via glass transition temperature (Tg) as thermo-responsive switch.•The developed nanofibrous membranes may be a potential candidate as targeted and responsive drug-delivery carrier. |
Author | Kim, Cheol Sang Fortunato, Giuseppino Brunelli, Marzia Spano, Fabrizio Amarjargal, Altangerel Rossi, René M. |
Author_xml | – sequence: 1 givenname: Altangerel surname: Amarjargal fullname: Amarjargal, Altangerel email: amaraa1@must.edu.mn organization: Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biomimetic Membranes and Textiles, CH-9014 St. Gallen, Switzerland – sequence: 2 givenname: Marzia surname: Brunelli fullname: Brunelli, Marzia organization: Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biomimetic Membranes and Textiles, CH-9014 St. Gallen, Switzerland – sequence: 3 givenname: Giuseppino surname: Fortunato fullname: Fortunato, Giuseppino organization: Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biomimetic Membranes and Textiles, CH-9014 St. Gallen, Switzerland – sequence: 4 givenname: Fabrizio orcidid: 0000-0003-2188-264X surname: Spano fullname: Spano, Fabrizio organization: Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biomimetic Membranes and Textiles, CH-9014 St. Gallen, Switzerland – sequence: 5 givenname: Cheol Sang surname: Kim fullname: Kim, Cheol Sang organization: Department of Bionanosystem Engineering, Chonbuk National University, Jeonju, Jeonbuk, 561-756, Republic of Korea – sequence: 6 givenname: René M. orcidid: 0000-0003-0946-682X surname: Rossi fullname: Rossi, René M. email: rene.rossi@empa.ch organization: Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biomimetic Membranes and Textiles, CH-9014 St. Gallen, Switzerland |
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Keywords | On-demand drug release Blended nanofibers Cytocompatibility Glass transition temperature |
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SubjectTerms | Blended nanofibers Cytocompatibility Glass transition temperature On-demand drug release |
Title | On-demand drug release from tailored blended electrospun nanofibers |
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